Cargando…
Chronic Obstructive Pulmonary Disease Increases the Risk of Hip Fracture: A Nationwide Population-Based Cohort Study
Hip fractures can lead to functional disability and high mortality rates among elderly patients. The aim of this study was to investigate whether chronic obstructive pulmonary disease (COPD) is a risk factor for hip fracture. A retrospective population-based 4-year cohort study was conducted using c...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796915/ https://www.ncbi.nlm.nih.gov/pubmed/26987933 http://dx.doi.org/10.1038/srep23360 |
_version_ | 1782421859749330944 |
---|---|
author | Huang, Shih-Wei Wang, Wei-Te Chou, Lin-Chuan Chen, Hung-Chou Liou, Tsan-Hon Lin, Hui-Wen |
author_facet | Huang, Shih-Wei Wang, Wei-Te Chou, Lin-Chuan Chen, Hung-Chou Liou, Tsan-Hon Lin, Hui-Wen |
author_sort | Huang, Shih-Wei |
collection | PubMed |
description | Hip fractures can lead to functional disability and high mortality rates among elderly patients. The aim of this study was to investigate whether chronic obstructive pulmonary disease (COPD) is a risk factor for hip fracture. A retrospective population-based 4-year cohort study was conducted using case–control matched analysis of data from the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005). Patients with a diagnosis of COPD between January 1, 2004 and December 31, 2007 were enrolled. A 2-stage approach and data from the National Health Interview Survey 2005 were applied to adjust for missing confounders in the LHID2005 cohort. Hazard ratios (HRs) and adjusted HRs were estimated hip fracture risk for the COPD. We enrolled 16,239 patients in the COPD cohort and 48,747 (1:3) patients in non-COPD cohort. The hip fracture incidences were 649 per 100,000 person-years in the study cohort and 369 per 100,000 person-years in non-COPD cohort. The hip fracture HR during the follow-up period was 1.78 (P < 0.001) and the adjusted hip fracture HR was 1.57 (P < 0.001) after adjustment for covariates by using the 2-stage approach method. Patients with COPD were at hip fracture risk and fracture-prevention strategies are essential for better quality of care. |
format | Online Article Text |
id | pubmed-4796915 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-47969152016-03-21 Chronic Obstructive Pulmonary Disease Increases the Risk of Hip Fracture: A Nationwide Population-Based Cohort Study Huang, Shih-Wei Wang, Wei-Te Chou, Lin-Chuan Chen, Hung-Chou Liou, Tsan-Hon Lin, Hui-Wen Sci Rep Article Hip fractures can lead to functional disability and high mortality rates among elderly patients. The aim of this study was to investigate whether chronic obstructive pulmonary disease (COPD) is a risk factor for hip fracture. A retrospective population-based 4-year cohort study was conducted using case–control matched analysis of data from the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005). Patients with a diagnosis of COPD between January 1, 2004 and December 31, 2007 were enrolled. A 2-stage approach and data from the National Health Interview Survey 2005 were applied to adjust for missing confounders in the LHID2005 cohort. Hazard ratios (HRs) and adjusted HRs were estimated hip fracture risk for the COPD. We enrolled 16,239 patients in the COPD cohort and 48,747 (1:3) patients in non-COPD cohort. The hip fracture incidences were 649 per 100,000 person-years in the study cohort and 369 per 100,000 person-years in non-COPD cohort. The hip fracture HR during the follow-up period was 1.78 (P < 0.001) and the adjusted hip fracture HR was 1.57 (P < 0.001) after adjustment for covariates by using the 2-stage approach method. Patients with COPD were at hip fracture risk and fracture-prevention strategies are essential for better quality of care. Nature Publishing Group 2016-03-18 /pmc/articles/PMC4796915/ /pubmed/26987933 http://dx.doi.org/10.1038/srep23360 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Huang, Shih-Wei Wang, Wei-Te Chou, Lin-Chuan Chen, Hung-Chou Liou, Tsan-Hon Lin, Hui-Wen Chronic Obstructive Pulmonary Disease Increases the Risk of Hip Fracture: A Nationwide Population-Based Cohort Study |
title | Chronic Obstructive Pulmonary Disease Increases the Risk of Hip Fracture: A Nationwide Population-Based Cohort Study |
title_full | Chronic Obstructive Pulmonary Disease Increases the Risk of Hip Fracture: A Nationwide Population-Based Cohort Study |
title_fullStr | Chronic Obstructive Pulmonary Disease Increases the Risk of Hip Fracture: A Nationwide Population-Based Cohort Study |
title_full_unstemmed | Chronic Obstructive Pulmonary Disease Increases the Risk of Hip Fracture: A Nationwide Population-Based Cohort Study |
title_short | Chronic Obstructive Pulmonary Disease Increases the Risk of Hip Fracture: A Nationwide Population-Based Cohort Study |
title_sort | chronic obstructive pulmonary disease increases the risk of hip fracture: a nationwide population-based cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796915/ https://www.ncbi.nlm.nih.gov/pubmed/26987933 http://dx.doi.org/10.1038/srep23360 |
work_keys_str_mv | AT huangshihwei chronicobstructivepulmonarydiseaseincreasestheriskofhipfractureanationwidepopulationbasedcohortstudy AT wangweite chronicobstructivepulmonarydiseaseincreasestheriskofhipfractureanationwidepopulationbasedcohortstudy AT choulinchuan chronicobstructivepulmonarydiseaseincreasestheriskofhipfractureanationwidepopulationbasedcohortstudy AT chenhungchou chronicobstructivepulmonarydiseaseincreasestheriskofhipfractureanationwidepopulationbasedcohortstudy AT lioutsanhon chronicobstructivepulmonarydiseaseincreasestheriskofhipfractureanationwidepopulationbasedcohortstudy AT linhuiwen chronicobstructivepulmonarydiseaseincreasestheriskofhipfractureanationwidepopulationbasedcohortstudy |