Detection of Vaccine-Induced Antibodies to Ebola Virus in Oral Fluid

Blood sampling to assess production of antigen-specific antibodies after immunization is commonly performed, but it presents logistical difficulties for trials carried out during an infectious disease outbreak. In this study, we show that antibodies may be reliably detected in oral fluid collected i...

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Autores principales: Lambe, Teresa, Rampling, Tommy, Samuel, Dhan, Bowyer, Georgina, Ewer, Katie J., Venkatraman, Navin, Edmans, Matthew, Dicks, Steve, Hill, Adrian V. S., Tedder, Richard S., Gilbert, Sarah C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796941/
https://www.ncbi.nlm.nih.gov/pubmed/27004234
http://dx.doi.org/10.1093/ofid/ofw031
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author Lambe, Teresa
Rampling, Tommy
Samuel, Dhan
Bowyer, Georgina
Ewer, Katie J.
Venkatraman, Navin
Edmans, Matthew
Dicks, Steve
Hill, Adrian V. S.
Tedder, Richard S.
Gilbert, Sarah C.
author_facet Lambe, Teresa
Rampling, Tommy
Samuel, Dhan
Bowyer, Georgina
Ewer, Katie J.
Venkatraman, Navin
Edmans, Matthew
Dicks, Steve
Hill, Adrian V. S.
Tedder, Richard S.
Gilbert, Sarah C.
author_sort Lambe, Teresa
collection PubMed
description Blood sampling to assess production of antigen-specific antibodies after immunization is commonly performed, but it presents logistical difficulties for trials carried out during an infectious disease outbreak. In this study, we show that antibodies may be reliably detected in oral fluid collected in a minimally invasive manner without use of sharps. Clinical Trials Registration. NCT02240875.
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spelling pubmed-47969412016-03-21 Detection of Vaccine-Induced Antibodies to Ebola Virus in Oral Fluid Lambe, Teresa Rampling, Tommy Samuel, Dhan Bowyer, Georgina Ewer, Katie J. Venkatraman, Navin Edmans, Matthew Dicks, Steve Hill, Adrian V. S. Tedder, Richard S. Gilbert, Sarah C. Open Forum Infect Dis Brief Reports Blood sampling to assess production of antigen-specific antibodies after immunization is commonly performed, but it presents logistical difficulties for trials carried out during an infectious disease outbreak. In this study, we show that antibodies may be reliably detected in oral fluid collected in a minimally invasive manner without use of sharps. Clinical Trials Registration. NCT02240875. Oxford University Press 2016-02-22 /pmc/articles/PMC4796941/ /pubmed/27004234 http://dx.doi.org/10.1093/ofid/ofw031 Text en © The Author 2016. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Reports
Lambe, Teresa
Rampling, Tommy
Samuel, Dhan
Bowyer, Georgina
Ewer, Katie J.
Venkatraman, Navin
Edmans, Matthew
Dicks, Steve
Hill, Adrian V. S.
Tedder, Richard S.
Gilbert, Sarah C.
Detection of Vaccine-Induced Antibodies to Ebola Virus in Oral Fluid
title Detection of Vaccine-Induced Antibodies to Ebola Virus in Oral Fluid
title_full Detection of Vaccine-Induced Antibodies to Ebola Virus in Oral Fluid
title_fullStr Detection of Vaccine-Induced Antibodies to Ebola Virus in Oral Fluid
title_full_unstemmed Detection of Vaccine-Induced Antibodies to Ebola Virus in Oral Fluid
title_short Detection of Vaccine-Induced Antibodies to Ebola Virus in Oral Fluid
title_sort detection of vaccine-induced antibodies to ebola virus in oral fluid
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796941/
https://www.ncbi.nlm.nih.gov/pubmed/27004234
http://dx.doi.org/10.1093/ofid/ofw031
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