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Daily rhythm of circulating fat soluble vitamin concentration (A, D, E and K) in the horse
BACKGROUND: Many physiological processes of mammalian species exhibit daily rhythmicity. An intrinsic relationship exists between fat soluble vitamins (A, D, E and K) and several body functions. Few investigations on the rhythmic pattern of vitamins in domestic animals have been carried out. The pre...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2004
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC479703/ https://www.ncbi.nlm.nih.gov/pubmed/15253770 http://dx.doi.org/10.1186/1740-3391-2-3 |
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author | Piccione, Giuseppe Assenza, Anna Grasso, Fortunata Caola, Giovanni |
author_facet | Piccione, Giuseppe Assenza, Anna Grasso, Fortunata Caola, Giovanni |
author_sort | Piccione, Giuseppe |
collection | PubMed |
description | BACKGROUND: Many physiological processes of mammalian species exhibit daily rhythmicity. An intrinsic relationship exists between fat soluble vitamins (A, D, E and K) and several body functions. Few investigations on the rhythmic pattern of vitamins in domestic animals have been carried out. The present study evaluated the circadian rhythmicity of fat soluble vitamins in the horse. METHODS: Blood samples from 5 Thoroughbred mares were collected at four-hour intervals over a 48-hour period (starting at 8:00 hours on day 1 and finishing at 4:00 on day 2) via an intravenous cannula inserted into the jugular vein. Fat soluble vitamin concentration in the serum (A, D, E and K) was measured by HPLC. One-way repeated measures analysis of variance (ANOVA) was used to determine significant differences. p values < 0.05 were considered statistically significant. RESULTS: ANOVA showed a highly significant effect of time in all the horses for the vitamins studied (p < 0.0001). The application of the periodic model and the statistical analysis of the "Cosinor" enabled us to define the periodic parameters and their acrophases (expressed in hours) during the 2 days of monitoring: all the studied vitamins showed diurnal acrophases with values between 15:16 and 18:08 hours. CONCLUSION: Fat soluble vitamins exhibit daily rhythmicity with diurnal peak. Further investigations could help optimize the use of these substances according to their circadian (or other) rhythms. |
format | Text |
id | pubmed-479703 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-4797032004-07-22 Daily rhythm of circulating fat soluble vitamin concentration (A, D, E and K) in the horse Piccione, Giuseppe Assenza, Anna Grasso, Fortunata Caola, Giovanni J Circadian Rhythms Short Paper BACKGROUND: Many physiological processes of mammalian species exhibit daily rhythmicity. An intrinsic relationship exists between fat soluble vitamins (A, D, E and K) and several body functions. Few investigations on the rhythmic pattern of vitamins in domestic animals have been carried out. The present study evaluated the circadian rhythmicity of fat soluble vitamins in the horse. METHODS: Blood samples from 5 Thoroughbred mares were collected at four-hour intervals over a 48-hour period (starting at 8:00 hours on day 1 and finishing at 4:00 on day 2) via an intravenous cannula inserted into the jugular vein. Fat soluble vitamin concentration in the serum (A, D, E and K) was measured by HPLC. One-way repeated measures analysis of variance (ANOVA) was used to determine significant differences. p values < 0.05 were considered statistically significant. RESULTS: ANOVA showed a highly significant effect of time in all the horses for the vitamins studied (p < 0.0001). The application of the periodic model and the statistical analysis of the "Cosinor" enabled us to define the periodic parameters and their acrophases (expressed in hours) during the 2 days of monitoring: all the studied vitamins showed diurnal acrophases with values between 15:16 and 18:08 hours. CONCLUSION: Fat soluble vitamins exhibit daily rhythmicity with diurnal peak. Further investigations could help optimize the use of these substances according to their circadian (or other) rhythms. BioMed Central 2004-07-15 /pmc/articles/PMC479703/ /pubmed/15253770 http://dx.doi.org/10.1186/1740-3391-2-3 Text en Copyright © 2004 Piccione et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
spellingShingle | Short Paper Piccione, Giuseppe Assenza, Anna Grasso, Fortunata Caola, Giovanni Daily rhythm of circulating fat soluble vitamin concentration (A, D, E and K) in the horse |
title | Daily rhythm of circulating fat soluble vitamin concentration (A, D, E and K) in the horse |
title_full | Daily rhythm of circulating fat soluble vitamin concentration (A, D, E and K) in the horse |
title_fullStr | Daily rhythm of circulating fat soluble vitamin concentration (A, D, E and K) in the horse |
title_full_unstemmed | Daily rhythm of circulating fat soluble vitamin concentration (A, D, E and K) in the horse |
title_short | Daily rhythm of circulating fat soluble vitamin concentration (A, D, E and K) in the horse |
title_sort | daily rhythm of circulating fat soluble vitamin concentration (a, d, e and k) in the horse |
topic | Short Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC479703/ https://www.ncbi.nlm.nih.gov/pubmed/15253770 http://dx.doi.org/10.1186/1740-3391-2-3 |
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