Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer

Signatures of mutagenesis provide a powerful tool for dissecting the role of somatic mutations in both normal and pathological processes. Significantly, cancer genomes are dominated by mutation signatures distinct from those that accumulate in normal tissues with age, with potentially important tran...

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Detalles Bibliográficos
Autores principales: Fox, Edward J., Salk, Jesse J., Loeb, Lawrence A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797182/
https://www.ncbi.nlm.nih.gov/pubmed/26987311
http://dx.doi.org/10.1186/s13073-016-0286-z
Descripción
Sumario:Signatures of mutagenesis provide a powerful tool for dissecting the role of somatic mutations in both normal and pathological processes. Significantly, cancer genomes are dominated by mutation signatures distinct from those that accumulate in normal tissues with age, with potentially important translational implications.

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