The miR-143/miR-145 cluster and the tumor microenvironment: unexpected roles

miR-143 and miR-145 have been widely described as tumor suppressors. Recent findings suggest these microRNAs (miRNAs) have a critical role that affects the stroma rather than epithelial cells. Understanding the part played by the miR-143/miR-145 cluster in the tumor microenvironment is essential for...

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Detalles Bibliográficos
Autores principales: Almeida, Maria Inês, Calin, George Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797185/
https://www.ncbi.nlm.nih.gov/pubmed/26988859
http://dx.doi.org/10.1186/s13073-016-0284-1
Descripción
Sumario:miR-143 and miR-145 have been widely described as tumor suppressors. Recent findings suggest these microRNAs (miRNAs) have a critical role that affects the stroma rather than epithelial cells. Understanding the part played by the miR-143/miR-145 cluster in the tumor microenvironment is essential for the development of future miRNA-related therapies.

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