The miR-143/miR-145 cluster and the tumor microenvironment: unexpected roles

miR-143 and miR-145 have been widely described as tumor suppressors. Recent findings suggest these microRNAs (miRNAs) have a critical role that affects the stroma rather than epithelial cells. Understanding the part played by the miR-143/miR-145 cluster in the tumor microenvironment is essential for...

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Detalles Bibliográficos
Autores principales: Almeida, Maria Inês, Calin, George Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797185/
https://www.ncbi.nlm.nih.gov/pubmed/26988859
http://dx.doi.org/10.1186/s13073-016-0284-1
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author Almeida, Maria Inês
Calin, George Adrian
author_facet Almeida, Maria Inês
Calin, George Adrian
author_sort Almeida, Maria Inês
collection PubMed
description miR-143 and miR-145 have been widely described as tumor suppressors. Recent findings suggest these microRNAs (miRNAs) have a critical role that affects the stroma rather than epithelial cells. Understanding the part played by the miR-143/miR-145 cluster in the tumor microenvironment is essential for the development of future miRNA-related therapies.
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spelling pubmed-47971852016-03-18 The miR-143/miR-145 cluster and the tumor microenvironment: unexpected roles Almeida, Maria Inês Calin, George Adrian Genome Med Comment miR-143 and miR-145 have been widely described as tumor suppressors. Recent findings suggest these microRNAs (miRNAs) have a critical role that affects the stroma rather than epithelial cells. Understanding the part played by the miR-143/miR-145 cluster in the tumor microenvironment is essential for the development of future miRNA-related therapies. BioMed Central 2016-03-17 /pmc/articles/PMC4797185/ /pubmed/26988859 http://dx.doi.org/10.1186/s13073-016-0284-1 Text en © Almeida and Calin. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Comment
Almeida, Maria Inês
Calin, George Adrian
The miR-143/miR-145 cluster and the tumor microenvironment: unexpected roles
title The miR-143/miR-145 cluster and the tumor microenvironment: unexpected roles
title_full The miR-143/miR-145 cluster and the tumor microenvironment: unexpected roles
title_fullStr The miR-143/miR-145 cluster and the tumor microenvironment: unexpected roles
title_full_unstemmed The miR-143/miR-145 cluster and the tumor microenvironment: unexpected roles
title_short The miR-143/miR-145 cluster and the tumor microenvironment: unexpected roles
title_sort mir-143/mir-145 cluster and the tumor microenvironment: unexpected roles
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797185/
https://www.ncbi.nlm.nih.gov/pubmed/26988859
http://dx.doi.org/10.1186/s13073-016-0284-1
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