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Improved knockdown from artificial microRNAs in an enhanced miR-155 backbone: a designer's guide to potent multi-target RNAi

Artificial microRNA (amiRNA) sequences embedded in natural microRNA (miRNA) backbones have proven to be useful tools for RNA interference (RNAi). amiRNAs have reduced off-target and toxic effects compared to other RNAi-based methods such as short-hairpin RNAs (shRNA). amiRNAs are often less effectiv...

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Detalles Bibliográficos
Autores principales:	Fowler, Daniel K., Williams, Carly, Gerritsen, Alida T., Washbourne, Philip
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Methods Online
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797272/ https://www.ncbi.nlm.nih.gov/pubmed/26582923 http://dx.doi.org/10.1093/nar/gkv1246

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