3CAPS – a structural AP–site analogue as a tool to investigate DNA base excision repair

Abasic sites (AP-sites) are frequent DNA lesions, arising by spontaneous base hydrolysis or as intermediates of base excision repair (BER). The hemiacetal at the anomeric centre renders them chemically reactive, which presents a challenge to biochemical and structural investigation. Chemically more...

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Detalles Bibliográficos
Autores principales: Schuermann, David, Scheidegger, Simon P., Weber, Alain R., Bjørås, Magnar, Leumann, Christian J., Schär, Primo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797279/
https://www.ncbi.nlm.nih.gov/pubmed/26733580
http://dx.doi.org/10.1093/nar/gkv1520

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