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Structures of replication initiation proteins from staphylococcal antibiotic resistance plasmids reveal protein asymmetry and flexibility are necessary for replication

Antibiotic resistance in pathogenic bacteria is a continual threat to human health, often residing in extrachromosomal plasmid DNA. Plasmids of the pT181 family are widespread and confer various antibiotic resistances to Staphylococcus aureus. They replicate via a rolling circle mechanism that requi...

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Detalles Bibliográficos
Autores principales:	Carr, Stephen B., Phillips, Simon E.V., Thomas, Christopher D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797284/ https://www.ncbi.nlm.nih.gov/pubmed/26792891 http://dx.doi.org/10.1093/nar/gkv1539

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