Next-generation bis-locked nucleic acids with stacking linker and 2′-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes

Targeting and invading double-stranded DNA with synthetic oligonucleotides under physiological conditions remain a challenge. Bis-locked nucleic acids (bisLNAs) are clamp-forming oligonucleotides able to invade into supercoiled DNA via combined Hoogsteen and Watson–Crick binding. To improve the bisL...

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Detalles Bibliográficos
Autores principales: Geny, Sylvain, Moreno, Pedro M. D., Krzywkowski, Tomasz, Gissberg, Olof, Andersen, Nicolai K., Isse, Abdirisaq J., El-Madani, Amro M., Lou, Chenguang, Pabon, Y. Vladimir, Anderson, Brooke A., Zaghloul, Eman M., Zain, Rula, Hrdlicka, Patrick J., Jørgensen, Per T., Nilsson, Mats, Lundin, Karin E., Pedersen, Erik B., Wengel, Jesper, Smith, C. I. Edvard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797291/
https://www.ncbi.nlm.nih.gov/pubmed/26857548
http://dx.doi.org/10.1093/nar/gkw021

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