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The landscape of somatic mutations in protein coding genes in apparently benign human tissues carries signatures of relaxed purifying selection
Mutations acquired during development and aging lead to inter- and intra-tissue genetic variations. Evidence linking such mutations to complex traits and diseases is rising. We detected somatic mutations in protein-coding regions in 140 benign tissue samples representing nine tissue-types (bladder,...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797307/ https://www.ncbi.nlm.nih.gov/pubmed/26883632 http://dx.doi.org/10.1093/nar/gkw086 |