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Structural and mutational analysis of archaeal ATP-dependent RNA ligase identifies amino acids required for RNA binding and catalysis

An ATP-dependent RNA ligase from Methanobacterium thermoautotrophicum (MthRnl) catalyzes intramolecular ligation of single-stranded RNA to form a closed circular RNA via covalent ligase-AMP and RNA-adenylylate intermediate. Here, we report the X-ray crystal structures of an MthRnl•ATP complex as wel...

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Detalles Bibliográficos
Autores principales:	Gu, Huiqiong, Yoshinari, Shigeo, Ghosh, Raka, Ignatochkina, Anna V., Gollnick, Paul D., Murakami, Katsuhiko S., Ho, C. Kiong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797309/ https://www.ncbi.nlm.nih.gov/pubmed/26896806 http://dx.doi.org/10.1093/nar/gkw094

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