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Excited‐State Dynamics of a Two‐Photon‐Activatable Ruthenium Prodrug

We present a new approach to investigate how the photodynamics of an octahedral ruthenium(II) complex activated through two‐photon absorption (TPA) differ from the equivalent complex activated through one‐photon absorption (OPA). We photoactivated a Ru(II) polypyridyl complex containing bioactive mo...

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Detalles Bibliográficos
Autores principales: Greenough, Simon E., Horbury, Michael D., Smith, Nichola A., Sadler, Peter J., Paterson, Martin J., Stavros, Vasilios G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797363/
https://www.ncbi.nlm.nih.gov/pubmed/26632426
http://dx.doi.org/10.1002/cphc.201501075
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author Greenough, Simon E.
Horbury, Michael D.
Smith, Nichola A.
Sadler, Peter J.
Paterson, Martin J.
Stavros, Vasilios G.
author_facet Greenough, Simon E.
Horbury, Michael D.
Smith, Nichola A.
Sadler, Peter J.
Paterson, Martin J.
Stavros, Vasilios G.
author_sort Greenough, Simon E.
collection PubMed
description We present a new approach to investigate how the photodynamics of an octahedral ruthenium(II) complex activated through two‐photon absorption (TPA) differ from the equivalent complex activated through one‐photon absorption (OPA). We photoactivated a Ru(II) polypyridyl complex containing bioactive monodentate ligands in the photodynamic therapy window (620–1000 nm) by using TPA and used transient UV/Vis absorption spectroscopy to elucidate its reaction pathways. Density functional calculations allowed us to identify the nature of the initially populated states and kinetic analysis recovers a photoactivation lifetime of approximately 100 ps. The dynamics displayed following TPA or OPA are identical, showing that TPA prodrug design may use knowledge gathered from the more numerous and easily conducted OPA studies.
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spelling pubmed-47973632016-03-21 Excited‐State Dynamics of a Two‐Photon‐Activatable Ruthenium Prodrug Greenough, Simon E. Horbury, Michael D. Smith, Nichola A. Sadler, Peter J. Paterson, Martin J. Stavros, Vasilios G. Chemphyschem Communications We present a new approach to investigate how the photodynamics of an octahedral ruthenium(II) complex activated through two‐photon absorption (TPA) differ from the equivalent complex activated through one‐photon absorption (OPA). We photoactivated a Ru(II) polypyridyl complex containing bioactive monodentate ligands in the photodynamic therapy window (620–1000 nm) by using TPA and used transient UV/Vis absorption spectroscopy to elucidate its reaction pathways. Density functional calculations allowed us to identify the nature of the initially populated states and kinetic analysis recovers a photoactivation lifetime of approximately 100 ps. The dynamics displayed following TPA or OPA are identical, showing that TPA prodrug design may use knowledge gathered from the more numerous and easily conducted OPA studies. John Wiley and Sons Inc. 2016-01-06 2016-01 /pmc/articles/PMC4797363/ /pubmed/26632426 http://dx.doi.org/10.1002/cphc.201501075 Text en © 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Greenough, Simon E.
Horbury, Michael D.
Smith, Nichola A.
Sadler, Peter J.
Paterson, Martin J.
Stavros, Vasilios G.
Excited‐State Dynamics of a Two‐Photon‐Activatable Ruthenium Prodrug
title Excited‐State Dynamics of a Two‐Photon‐Activatable Ruthenium Prodrug
title_full Excited‐State Dynamics of a Two‐Photon‐Activatable Ruthenium Prodrug
title_fullStr Excited‐State Dynamics of a Two‐Photon‐Activatable Ruthenium Prodrug
title_full_unstemmed Excited‐State Dynamics of a Two‐Photon‐Activatable Ruthenium Prodrug
title_short Excited‐State Dynamics of a Two‐Photon‐Activatable Ruthenium Prodrug
title_sort excited‐state dynamics of a two‐photon‐activatable ruthenium prodrug
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797363/
https://www.ncbi.nlm.nih.gov/pubmed/26632426
http://dx.doi.org/10.1002/cphc.201501075
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