Insights into 6‐Methylsalicylic Acid Bio‐assembly by Using Chemical Probes

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Chemical probes capable of reacting with KS (ketosynthase)‐bound biosynthetic intermediates were utilized for the investigation of the model type I iterative polyketide synthase 6‐methylsalicylic acid synthase (6‐MSAS) in vivo and in vitro. From the fermentation of fungal and bacterial 6‐MSAS hosts...

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Detalles Bibliográficos
Autores principales: Parascandolo, James S., Havemann, Judith, Potter, Helen K., Huang, Fanglu, Riva, Elena, Connolly, Jack, Wilkening, Ina, Song, Lijiang, Leadlay, Peter F., Tosin, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797705/
https://www.ncbi.nlm.nih.gov/pubmed/26833898
http://dx.doi.org/10.1002/anie.201509038

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