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The MRX Complex Ensures NHEJ Fidelity through Multiple Pathways Including Xrs2-FHA–Dependent Tel1 Activation

Because DNA double-strand breaks (DSBs) are one of the most cytotoxic DNA lesions and often cause genomic instability, precise repair of DSBs is vital for the maintenance of genomic stability. Xrs2/Nbs1 is a multi-functional regulatory subunit of the Mre11-Rad50-Xrs2/Nbs1 (MRX/N) complex, and its fu...

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Detalles Bibliográficos
Autores principales:	Iwasaki, Daichi, Hayashihara, Kayoko, Shima, Hiroki, Higashide, Mika, Terasawa, Masahiro, Gasser, Susan M., Shinohara, Miki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798412/ https://www.ncbi.nlm.nih.gov/pubmed/26990569 http://dx.doi.org/10.1371/journal.pgen.1005942

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