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TP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone in Xpa-deficient human TP53 knock-in mouse embryo fibroblasts

3-Nitrobenzanthrone (3-NBA) is a highly mutagenic compound and possible human carcinogen found in diesel exhaust. 3-NBA forms bulky DNA adducts following metabolic activation and induces predominantly G:C > T:A transversions in a variety of experimental systems. Here we investigated the influence...

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Detalles Bibliográficos
Autores principales:	Kucab, Jill E., Zwart, Edwin P., van Steeg, Harry, Luijten, Mirjam, Schmeiser, Heinz H., Phillips, David H., Arlt, Volker M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798848/ https://www.ncbi.nlm.nih.gov/pubmed/26723900 http://dx.doi.org/10.1016/j.dnarep.2015.11.004

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