Discovery of Tumor-Specific Irreversible Inhibitors of Stearoyl CoA Desaturase

A hallmark of targeted cancer therapies is selective toxicity among cancer cell lines. We evaluated results from a viability screen of over 200,000 small molecules to identify two chemical series, oxalamides and benzothiazoles, that were selectively toxic to the same four of 12 human lung cancer cel...

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Detalles Bibliográficos
Autores principales: Theodoropoulos, Panayotis C., Gonzales, Stephen S., Winterton, Sarah E., Rodriguez-Navas, Carlos, McKnight, John S., Morlock, Lorraine K., Hanson, Jordan M., Cross, Bethany, Owen, Amy E., Duan, Yingli, Moreno, Jose R., Lemoff, Andrew, Mirzaei, Hamid, Posner, Bruce A., Williams, Noelle S., Ready, Joseph M., Nijhawan, Deepak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798879/
https://www.ncbi.nlm.nih.gov/pubmed/26829472
http://dx.doi.org/10.1038/nchembio.2016

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