Cargando…

Active machine learning-driven experimentation to determine compound effects on protein patterns

High throughput screening determines the effects of many conditions on a given biological target. Currently, to estimate the effects of those conditions on other targets requires either strong modeling assumptions (e.g. similarities among targets) or separate screens. Ideally, data-driven experiment...

Descripción completa

Detalles Bibliográficos
Autores principales:	Naik, Armaghan W, Kangas, Joshua D, Sullivan, Devin P, Murphy, Robert F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798950/ https://www.ncbi.nlm.nih.gov/pubmed/26840049 http://dx.doi.org/10.7554/eLife.10047

Ejemplares similares

Efficient discovery of responses of proteins to compounds using active learning
por: Kangas, Joshua D, et al.
Publicado: (2014)

Efficient Modeling and Active Learning Discovery of Biological Responses
por: Naik, Armaghan W., et al.
Publicado: (2013)

Deciding when to stop: efficient experimentation to learn to predict drug-target interactions
por: Temerinac-Ott, Maja, et al.
Publicado: (2015)

Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation
por: Bolger-Munro, Madison, et al.
Publicado: (2019)

A Degenerate Peptide Library Approach to Reveal Sequence Determinants of Methyllysine-Driven Protein Interactions
por: Kupai, Ariana, et al.
Publicado: (2020)

Editorial: Mechanisms of hox-driven patterning and morphogenesis
por: Kmita, Marie, et al.
Publicado: (2022)

Non-invasive classification of macrophage polarisation by 2P-FLIM and machine learning
por: Neto, Nuno GB, et al.
Publicado: (2022)

CytoCensus, mapping cell identity and division in tissues and organs using machine learning
por: Hailstone, Martin, et al.
Publicado: (2020)

Live cell-lineage tracing and machine learning reveal patterns of organ regeneration
por: Viader-Llargués, Oriol, et al.
Publicado: (2018)

Quantification of Osteoclasts in Culture, Powered by Machine Learning
por: Cohen-Karlik, Edo, et al.
Publicado: (2021)

Endogenous RNA interference is driven by copy number
por: Cruz, Cristina, et al.
Publicado: (2014)

Correction: Endogenous RNA interference is driven by copy number
por: Cruz, Cristina, et al.
Publicado: (2015)

Identification of Genome Sequences of Polyphosphate-Accumulating Organisms by Machine Learning
por: Liu, Bohan, et al.
Publicado: (2021)

The Characterization of Structure and Prediction for Aquaporin in Tumour Progression by Machine Learning
por: Chen, Zheng, et al.
Publicado: (2022)

Machine learning identifies exosome features related to hepatocellular carcinoma
por: Zhu, Kai, et al.
Publicado: (2022)

Kinetochore-independent chromosome segregation driven by lateral microtubule bundles
por: Muscat, Christina C, et al.
Publicado: (2015)

The role of scaffold reshaping and disassembly in dynamin driven membrane fission
por: Pannuzzo, Martina, et al.
Publicado: (2018)

Conserved structural elements specialize ATAD1 as a membrane protein extraction machine
por: Wang, Lan, et al.
Publicado: (2022)

A role for PVRL4-driven cell–cell interactions in tumorigenesis
por: Pavlova, Natalya N, et al.
Publicado: (2013)

Generation of stress fibers through myosin-driven reorganization of the actin cortex
por: Lehtimäki, Jaakko I, et al.
Publicado: (2021)

Screening of a natural compound library identifies emodin, a natural compound from Rheum palmatum Linn that inhibits DPP4
por: Wang, Zhaokai, et al.
Publicado: (2017)

Identify Inflammatory Bowel Disease-Related Genes Based on Machine Learning
por: Ye, Lili, et al.
Publicado: (2021)

Correction: Generation of stress fibers through myosin-driven reorganization of the actin cortex
por: Lehtimäki, Jaakko I, et al.
Publicado: (2022)

Large Scale Identification of Osteosarcoma Pathogenic Genes by Multiple Extreme Learning Machine
por: Zhao, Zhipeng, et al.
Publicado: (2021)

Delineation of proteome changes driven by cell size and growth rate
por: Zatulovskiy, Evgeny, et al.
Publicado: (2022)

Robust T cell activation requires an eIF3-driven burst in T cell receptor translation
por: De Silva, Dasmanthie, et al.
Publicado: (2021)

Machine learning–driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins
por: Ingólfsson, Helgi I., et al.
Publicado: (2022)

Covalent Label Transfer between Peroxisomal Importomer Components Reveals Export-driven Import Interactions
por: Bhogal, Moninder S., et al.
Publicado: (2016)

A disassembly-driven mechanism explains F-actin-mediated chromosome transport in starfish oocytes
por: Bun, Philippe, et al.
Publicado: (2018)

Inhibition of hyaluronan secretion by novel coumarin compounds and chitin synthesis inhibitors
por: Tsitrina, Alexandra A, et al.
Publicado: (2021)

Punicalagin, a pomegranate compound, induces apoptosis and autophagy in acute leukemia
por: Subkorn, Paweena, et al.
Publicado: (2021)

Integrative Analysis of Biomarkers Through Machine Learning Identifies Stemness Features in Colorectal Cancer
por: Wei, Ran, et al.
Publicado: (2021)

Identification and Validation of the Pyroptosis-Related Molecular Subtypes of Lung Adenocarcinoma by Bioinformatics and Machine Learning
por: Liu, Le-Ping, et al.
Publicado: (2021)

Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins
por: Harmon, Tyler S, et al.
Publicado: (2017)

CM1-driven assembly and activation of yeast γ-tubulin small complex underlies microtubule nucleation
por: Brilot, Axel F, et al.
Publicado: (2021)

Anti-leukemic effect of menthol, a peppermint compound, on induction of apoptosis and autophagy
por: Naksawat, Mashima, et al.
Publicado: (2023)

An FGF-driven feed-forward circuit patterns the cardiopharyngeal mesoderm in space and time
por: Razy-Krajka, Florian, et al.
Publicado: (2018)

Neutrophil Migratory Patterns: Implications for Cardiovascular Disease
por: Dahdah, Albert, et al.
Publicado: (2022)

Discovery and functional assessment of a novel adipocyte population driven by intracellular Wnt/β-catenin signaling in mammals
por: Liu, Zhi, et al.
Publicado: (2022)

Early Diagnosis of Pancreatic Ductal Adenocarcinoma by Combining Relative Expression Orderings With Machine-Learning Method
por: Zhang, Zi-Mei, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_6euso5skks6uo7ll7jemopib2i