Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis

Rho-associated kinases 1 and 2 (ROCK1/2) are Rho-GTPase effectors that control key aspects of the actin cytoskeleton, but their role in proliferation and cancer initiation or progression is not known. Here, we provide evidence that ROCK1 and ROCK2 act redundantly to maintain actomyosin contractility...

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Detalles Bibliográficos
Autores principales: Kümper, Sandra, Mardakheh, Faraz K, McCarthy, Afshan, Yeo, Maggie, Stamp, Gordon W, Paul, Angela, Worboys, Jonathan, Sadok, Amine, Jørgensen, Claus, Guichard, Sabrina, Marshall, Christopher J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798951/
https://www.ncbi.nlm.nih.gov/pubmed/26765561
http://dx.doi.org/10.7554/eLife.12203

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