The autophagy gene Atg16l1 differentially regulates T(reg) and T(H)2 cells to control intestinal inflammation

A polymorphism in the autophagy gene Atg16l1 is associated with susceptibility to inflammatory bowel disease (IBD); however, it remains unclear how autophagy contributes to intestinal immune homeostasis. Here, we demonstrate that autophagy is essential for maintenance of balanced CD4(+) T cell respo...

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Detalles Bibliográficos
Autores principales: Kabat, Agnieszka M, Harrison, Oliver J, Riffelmacher, Thomas, Moghaddam, Amin E, Pearson, Claire F, Laing, Adam, Abeler-Dörner, Lucie, Forman, Simon P, Grencis, Richard K, Sattentau, Quentin, Simon, Anna Katharina, Pott, Johanna, Maloy, Kevin J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798959/
https://www.ncbi.nlm.nih.gov/pubmed/26910010
http://dx.doi.org/10.7554/eLife.12444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798959/
https://www.ncbi.nlm.nih.gov/pubmed/26910010
http://dx.doi.org/10.7554/eLife.12444

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