Regulatory consequences of neuronal ELAV-like protein binding to coding and non-coding RNAs in human brain

Neuronal ELAV-like (nELAVL) RNA binding proteins have been linked to numerous neurological disorders. We performed crosslinking-immunoprecipitation and RNAseq on human brain, and identified nELAVL binding sites on 8681 transcripts. Using knockout mice and RNAi in human neuroblastoma cells, we showed...

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Detalles Bibliográficos
Autores principales: Scheckel, Claudia, Drapeau, Elodie, Frias, Maria A, Park, Christopher Y, Fak, John, Zucker-Scharff, Ilana, Kou, Yan, Haroutunian, Vahram, Ma'ayan, Avi, Buxbaum, Joseph D, Darnell, Robert B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798961/
https://www.ncbi.nlm.nih.gov/pubmed/26894958
http://dx.doi.org/10.7554/eLife.10421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798961/
https://www.ncbi.nlm.nih.gov/pubmed/26894958
http://dx.doi.org/10.7554/eLife.10421

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