RANDOMIZED CONTROLLED CLINICAL TRIALS IN ORTHOPEDICS: DIFFICULTIES AND LIMITATIONS

Randomized controlled clinical trials (RCTs) are considered to be the gold standard for evidence-based medicine nowadays, and are important for directing medical practice through consistent scientific observations. Steps such as patient selection, randomization and blinding are fundamental for condu...

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Detalles Bibliográficos
Autores principales: Malavolta, Eduardo Angeli, Demange, Marco Kawamura, Gobbi, Riccardo Gomes, Imamura, Marta, Fregni, Felipe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799300/
https://www.ncbi.nlm.nih.gov/pubmed/27027037
http://dx.doi.org/10.1016/S2255-4971(15)30261-5
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author Malavolta, Eduardo Angeli
Demange, Marco Kawamura
Gobbi, Riccardo Gomes
Imamura, Marta
Fregni, Felipe
author_facet Malavolta, Eduardo Angeli
Demange, Marco Kawamura
Gobbi, Riccardo Gomes
Imamura, Marta
Fregni, Felipe
author_sort Malavolta, Eduardo Angeli
collection PubMed
description Randomized controlled clinical trials (RCTs) are considered to be the gold standard for evidence-based medicine nowadays, and are important for directing medical practice through consistent scientific observations. Steps such as patient selection, randomization and blinding are fundamental for conducting a RCT, but some additional difficulties are presented in trials that involve surgical procedures, as is common in orthopedics. The aim of this article was to highlight and discuss some difficulties and possible limitations on RCTs within the field of surgery.
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spelling pubmed-47993002016-03-29 RANDOMIZED CONTROLLED CLINICAL TRIALS IN ORTHOPEDICS: DIFFICULTIES AND LIMITATIONS Malavolta, Eduardo Angeli Demange, Marco Kawamura Gobbi, Riccardo Gomes Imamura, Marta Fregni, Felipe Rev Bras Ortop Review Article Randomized controlled clinical trials (RCTs) are considered to be the gold standard for evidence-based medicine nowadays, and are important for directing medical practice through consistent scientific observations. Steps such as patient selection, randomization and blinding are fundamental for conducting a RCT, but some additional difficulties are presented in trials that involve surgical procedures, as is common in orthopedics. The aim of this article was to highlight and discuss some difficulties and possible limitations on RCTs within the field of surgery. Elsevier 2015-11-17 /pmc/articles/PMC4799300/ /pubmed/27027037 http://dx.doi.org/10.1016/S2255-4971(15)30261-5 Text en © 2011 Sociedade Brasileira de Ortopedia e Traumatologia http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Malavolta, Eduardo Angeli
Demange, Marco Kawamura
Gobbi, Riccardo Gomes
Imamura, Marta
Fregni, Felipe
RANDOMIZED CONTROLLED CLINICAL TRIALS IN ORTHOPEDICS: DIFFICULTIES AND LIMITATIONS
title RANDOMIZED CONTROLLED CLINICAL TRIALS IN ORTHOPEDICS: DIFFICULTIES AND LIMITATIONS
title_full RANDOMIZED CONTROLLED CLINICAL TRIALS IN ORTHOPEDICS: DIFFICULTIES AND LIMITATIONS
title_fullStr RANDOMIZED CONTROLLED CLINICAL TRIALS IN ORTHOPEDICS: DIFFICULTIES AND LIMITATIONS
title_full_unstemmed RANDOMIZED CONTROLLED CLINICAL TRIALS IN ORTHOPEDICS: DIFFICULTIES AND LIMITATIONS
title_short RANDOMIZED CONTROLLED CLINICAL TRIALS IN ORTHOPEDICS: DIFFICULTIES AND LIMITATIONS
title_sort randomized controlled clinical trials in orthopedics: difficulties and limitations
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799300/
https://www.ncbi.nlm.nih.gov/pubmed/27027037
http://dx.doi.org/10.1016/S2255-4971(15)30261-5
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