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HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults
Outcomes of chronic infection with hepatitis B virus (HBV) are varied, with increased morbidity reported in the context of human immunodeficiency virus (HIV) coinfection. The factors driving different outcomes are not well understood, but there is increasing interest in an HLA class I effect. We the...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799671/ https://www.ncbi.nlm.nih.gov/pubmed/26655301 http://dx.doi.org/10.1093/infdis/jiv592 |
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author | Matthews, Philippa C. Carlson, Jonathan M. Beloukas, Apostolos Malik, Amna Jooste, Pieter Ogwu, Anthony Shapiro, Roger Riddell, Lynn Chen, Fabian Luzzi, Graz Jesuthasan, Gerald Jeffery, Katie Jojic, Nebojsa Ndung'u, Thumbi Carrington, Mary Goulder, Philip J. R. Geretti, Anna Maria Klenerman, Paul |
author_facet | Matthews, Philippa C. Carlson, Jonathan M. Beloukas, Apostolos Malik, Amna Jooste, Pieter Ogwu, Anthony Shapiro, Roger Riddell, Lynn Chen, Fabian Luzzi, Graz Jesuthasan, Gerald Jeffery, Katie Jojic, Nebojsa Ndung'u, Thumbi Carrington, Mary Goulder, Philip J. R. Geretti, Anna Maria Klenerman, Paul |
author_sort | Matthews, Philippa C. |
collection | PubMed |
description | Outcomes of chronic infection with hepatitis B virus (HBV) are varied, with increased morbidity reported in the context of human immunodeficiency virus (HIV) coinfection. The factors driving different outcomes are not well understood, but there is increasing interest in an HLA class I effect. We therefore studied the influence of HLA class I on HBV in an African HIV-positive cohort. We demonstrated that virologic markers of HBV disease activity (hepatitis B e antigen status or HBV DNA level) are associated with HLA-A genotype. This finding supports the role of the CD8(+) T-cell response in HBV control, and potentially informs future therapeutic T-cell vaccine strategies. |
format | Online Article Text |
id | pubmed-4799671 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-47996712016-03-21 HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults Matthews, Philippa C. Carlson, Jonathan M. Beloukas, Apostolos Malik, Amna Jooste, Pieter Ogwu, Anthony Shapiro, Roger Riddell, Lynn Chen, Fabian Luzzi, Graz Jesuthasan, Gerald Jeffery, Katie Jojic, Nebojsa Ndung'u, Thumbi Carrington, Mary Goulder, Philip J. R. Geretti, Anna Maria Klenerman, Paul J Infect Dis Major Articles and Brief Reports Outcomes of chronic infection with hepatitis B virus (HBV) are varied, with increased morbidity reported in the context of human immunodeficiency virus (HIV) coinfection. The factors driving different outcomes are not well understood, but there is increasing interest in an HLA class I effect. We therefore studied the influence of HLA class I on HBV in an African HIV-positive cohort. We demonstrated that virologic markers of HBV disease activity (hepatitis B e antigen status or HBV DNA level) are associated with HLA-A genotype. This finding supports the role of the CD8(+) T-cell response in HBV control, and potentially informs future therapeutic T-cell vaccine strategies. Oxford University Press 2016-04-15 2015-12-09 /pmc/articles/PMC4799671/ /pubmed/26655301 http://dx.doi.org/10.1093/infdis/jiv592 Text en © The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Major Articles and Brief Reports Matthews, Philippa C. Carlson, Jonathan M. Beloukas, Apostolos Malik, Amna Jooste, Pieter Ogwu, Anthony Shapiro, Roger Riddell, Lynn Chen, Fabian Luzzi, Graz Jesuthasan, Gerald Jeffery, Katie Jojic, Nebojsa Ndung'u, Thumbi Carrington, Mary Goulder, Philip J. R. Geretti, Anna Maria Klenerman, Paul HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults |
title | HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults |
title_full | HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults |
title_fullStr | HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults |
title_full_unstemmed | HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults |
title_short | HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults |
title_sort | hla-a is a predictor of hepatitis b e antigen status in hiv-positive african adults |
topic | Major Articles and Brief Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799671/ https://www.ncbi.nlm.nih.gov/pubmed/26655301 http://dx.doi.org/10.1093/infdis/jiv592 |
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