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Artemisia annua Leaf Extract Attenuates Hepatic Steatosis and Inflammation in High-Fat Diet-Fed Mice
Artemisia annua L. (AA) is a well-known source of the antimalarial drug artemisinin. AA also has an antibacterial and antioxidant activity. However, the effect of AA extract on hepatic steatosis induced by obesity is unclear. We investigated whether AA extract prevents obesity-induced insulin resist...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mary Ann Liebert, Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799707/ https://www.ncbi.nlm.nih.gov/pubmed/26741655 http://dx.doi.org/10.1089/jmf.2015.3527 |
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author | Kim, Kyung Eun Ko, Keon-Hee Heo, Rok Won Yi, Chin-ok Shin, Hyun Joo Kim, Jun Young Park, Jae-Ho Nam, Sanghae Kim, Hwajin Roh, Gu Seob |
author_facet | Kim, Kyung Eun Ko, Keon-Hee Heo, Rok Won Yi, Chin-ok Shin, Hyun Joo Kim, Jun Young Park, Jae-Ho Nam, Sanghae Kim, Hwajin Roh, Gu Seob |
author_sort | Kim, Kyung Eun |
collection | PubMed |
description | Artemisia annua L. (AA) is a well-known source of the antimalarial drug artemisinin. AA also has an antibacterial and antioxidant activity. However, the effect of AA extract on hepatic steatosis induced by obesity is unclear. We investigated whether AA extract prevents obesity-induced insulin resistance and hepatic steatosis in high-fat diet (HFD)-fed mice. Mice were randomly divided into groups that received a normal chow diet or HFD with or without AA for 12 weeks. We found that AA extract reduced insulin resistance and hepatic steatosis in HFD-fed mice. Western blot analysis showed that HFD-induced expression of nuclear sterol regulatory element-binding protein 1 and carbohydrate-responsive element-binding protein in the livers was decreased by AA extract. In particular, dietary administration of AA extract decreased hepatic high-mobility group box 1 and cyclooxygenase-2 expression in HFD-fed mice. AA extract also attenuated HFD-induced collagen deposition and fibrosis-related transforming growth factor-β1 and connective tissue growth factor. These data indicate that dietary AA extract has beneficial effects on hepatic steatosis and inflammation in HFD-fed mice. |
format | Online Article Text |
id | pubmed-4799707 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Mary Ann Liebert, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-47997072016-03-24 Artemisia annua Leaf Extract Attenuates Hepatic Steatosis and Inflammation in High-Fat Diet-Fed Mice Kim, Kyung Eun Ko, Keon-Hee Heo, Rok Won Yi, Chin-ok Shin, Hyun Joo Kim, Jun Young Park, Jae-Ho Nam, Sanghae Kim, Hwajin Roh, Gu Seob J Med Food Full Communications Artemisia annua L. (AA) is a well-known source of the antimalarial drug artemisinin. AA also has an antibacterial and antioxidant activity. However, the effect of AA extract on hepatic steatosis induced by obesity is unclear. We investigated whether AA extract prevents obesity-induced insulin resistance and hepatic steatosis in high-fat diet (HFD)-fed mice. Mice were randomly divided into groups that received a normal chow diet or HFD with or without AA for 12 weeks. We found that AA extract reduced insulin resistance and hepatic steatosis in HFD-fed mice. Western blot analysis showed that HFD-induced expression of nuclear sterol regulatory element-binding protein 1 and carbohydrate-responsive element-binding protein in the livers was decreased by AA extract. In particular, dietary administration of AA extract decreased hepatic high-mobility group box 1 and cyclooxygenase-2 expression in HFD-fed mice. AA extract also attenuated HFD-induced collagen deposition and fibrosis-related transforming growth factor-β1 and connective tissue growth factor. These data indicate that dietary AA extract has beneficial effects on hepatic steatosis and inflammation in HFD-fed mice. Mary Ann Liebert, Inc. 2016-03-01 /pmc/articles/PMC4799707/ /pubmed/26741655 http://dx.doi.org/10.1089/jmf.2015.3527 Text en © Kyung Eun Kim et al. 2015; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Full Communications Kim, Kyung Eun Ko, Keon-Hee Heo, Rok Won Yi, Chin-ok Shin, Hyun Joo Kim, Jun Young Park, Jae-Ho Nam, Sanghae Kim, Hwajin Roh, Gu Seob Artemisia annua Leaf Extract Attenuates Hepatic Steatosis and Inflammation in High-Fat Diet-Fed Mice |
title | Artemisia annua Leaf Extract Attenuates Hepatic Steatosis and Inflammation in High-Fat Diet-Fed Mice |
title_full | Artemisia annua Leaf Extract Attenuates Hepatic Steatosis and Inflammation in High-Fat Diet-Fed Mice |
title_fullStr | Artemisia annua Leaf Extract Attenuates Hepatic Steatosis and Inflammation in High-Fat Diet-Fed Mice |
title_full_unstemmed | Artemisia annua Leaf Extract Attenuates Hepatic Steatosis and Inflammation in High-Fat Diet-Fed Mice |
title_short | Artemisia annua Leaf Extract Attenuates Hepatic Steatosis and Inflammation in High-Fat Diet-Fed Mice |
title_sort | artemisia annua leaf extract attenuates hepatic steatosis and inflammation in high-fat diet-fed mice |
topic | Full Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799707/ https://www.ncbi.nlm.nih.gov/pubmed/26741655 http://dx.doi.org/10.1089/jmf.2015.3527 |
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