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Quality of Sulfadoxine-Pyrimethamine Given as Antimalarial Prophylaxis in Pregnant Women in Selected Health Facilities in Central Region of Ghana

The use of sulfadoxine-pyrimethamine (SP) as an intermittent preventive treatment (IPT) against malaria during pregnancy has become a policy in most sub-Sahara African countries and crucially depends on the efficacy of SP. This study sets out to evaluate the effectiveness of the SP given to the preg...

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Autores principales: Yeboah, Danny F., Afoakwah, Richmond, Nwaefuna, Ekene K., Verner, Orish, Boampong, Johnson N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799813/
https://www.ncbi.nlm.nih.gov/pubmed/27042341
http://dx.doi.org/10.1155/2016/9231946
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author Yeboah, Danny F.
Afoakwah, Richmond
Nwaefuna, Ekene K.
Verner, Orish
Boampong, Johnson N.
author_facet Yeboah, Danny F.
Afoakwah, Richmond
Nwaefuna, Ekene K.
Verner, Orish
Boampong, Johnson N.
author_sort Yeboah, Danny F.
collection PubMed
description The use of sulfadoxine-pyrimethamine (SP) as an intermittent preventive treatment (IPT) against malaria during pregnancy has become a policy in most sub-Sahara African countries and crucially depends on the efficacy of SP. This study sets out to evaluate the effectiveness of the SP given to the pregnant women in some selected health facilities in the Central Region of Ghana to prevent maternal malaria in pregnant women. A total of 543 pregnant women recruited from 7 selected health centres in Central Region of Ghana participated in the study. Parasite density of Plasmodium falciparum was determined from peripheral blood of the pregnant women using microscopy. High performance liquid chromatography (HPLC) and dissolution tester were used to determine the quality of the SP. Malaria infection was recorded in 11.2% of pregnant women who had a history of SP consumption. SP failed the dissolution test. Pregnant women who did not receive IPT-SP were 44%. Low haemoglobin level was recorded in 73.5% of the pregnant women. The results indicated that SP was substandard. IPT-SP is ineffective in preventing malaria infection.
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spelling pubmed-47998132016-04-03 Quality of Sulfadoxine-Pyrimethamine Given as Antimalarial Prophylaxis in Pregnant Women in Selected Health Facilities in Central Region of Ghana Yeboah, Danny F. Afoakwah, Richmond Nwaefuna, Ekene K. Verner, Orish Boampong, Johnson N. J Parasitol Res Research Article The use of sulfadoxine-pyrimethamine (SP) as an intermittent preventive treatment (IPT) against malaria during pregnancy has become a policy in most sub-Sahara African countries and crucially depends on the efficacy of SP. This study sets out to evaluate the effectiveness of the SP given to the pregnant women in some selected health facilities in the Central Region of Ghana to prevent maternal malaria in pregnant women. A total of 543 pregnant women recruited from 7 selected health centres in Central Region of Ghana participated in the study. Parasite density of Plasmodium falciparum was determined from peripheral blood of the pregnant women using microscopy. High performance liquid chromatography (HPLC) and dissolution tester were used to determine the quality of the SP. Malaria infection was recorded in 11.2% of pregnant women who had a history of SP consumption. SP failed the dissolution test. Pregnant women who did not receive IPT-SP were 44%. Low haemoglobin level was recorded in 73.5% of the pregnant women. The results indicated that SP was substandard. IPT-SP is ineffective in preventing malaria infection. Hindawi Publishing Corporation 2016 2016-03-06 /pmc/articles/PMC4799813/ /pubmed/27042341 http://dx.doi.org/10.1155/2016/9231946 Text en Copyright © 2016 Danny F. Yeboah et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yeboah, Danny F.
Afoakwah, Richmond
Nwaefuna, Ekene K.
Verner, Orish
Boampong, Johnson N.
Quality of Sulfadoxine-Pyrimethamine Given as Antimalarial Prophylaxis in Pregnant Women in Selected Health Facilities in Central Region of Ghana
title Quality of Sulfadoxine-Pyrimethamine Given as Antimalarial Prophylaxis in Pregnant Women in Selected Health Facilities in Central Region of Ghana
title_full Quality of Sulfadoxine-Pyrimethamine Given as Antimalarial Prophylaxis in Pregnant Women in Selected Health Facilities in Central Region of Ghana
title_fullStr Quality of Sulfadoxine-Pyrimethamine Given as Antimalarial Prophylaxis in Pregnant Women in Selected Health Facilities in Central Region of Ghana
title_full_unstemmed Quality of Sulfadoxine-Pyrimethamine Given as Antimalarial Prophylaxis in Pregnant Women in Selected Health Facilities in Central Region of Ghana
title_short Quality of Sulfadoxine-Pyrimethamine Given as Antimalarial Prophylaxis in Pregnant Women in Selected Health Facilities in Central Region of Ghana
title_sort quality of sulfadoxine-pyrimethamine given as antimalarial prophylaxis in pregnant women in selected health facilities in central region of ghana
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799813/
https://www.ncbi.nlm.nih.gov/pubmed/27042341
http://dx.doi.org/10.1155/2016/9231946
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