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P2Y(12) receptor blockade synergizes strongly with nitric oxide and prostacyclin to inhibit platelet activation

AIMS: In vivo platelet function is a product of intrinsic platelet reactivity, modifiable by dual antiplatelet therapy (DAPT), and the extrinsic inhibitory endothelial mediators, nitric oxide (NO) and prostacyclin (PGI(2)), that are powerfully potentiated by P2Y(12) receptor blockade. This implies t...

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Detalles Bibliográficos
Autores principales:	Chan, Melissa V., Knowles, Rebecca B. M., Lundberg, Martina H., Tucker, Arthur T., Mohamed, Nura A., Kirkby, Nicholas S., Armstrong, Paul C. J., Mitchell, Jane A., Warner, Timothy D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Translational Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799935/ https://www.ncbi.nlm.nih.gov/pubmed/26561399 http://dx.doi.org/10.1111/bcp.12826

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