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MiR-200a Suppresses the Proliferation and Metastasis in Pancreatic Ductal Adenocarcinoma through Downregulation of DEK Gene()

MiR-200a has been reported to be able to suppress the epithelial-mesenchymal transition process in pancreatic cancer stem cells, suggesting that miR-200a could suppress the metastasis of pancreatic ductal adenocarcinoma (PDAC). However, its role in proliferation and metastasis of PDAC and the underl...

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Autores principales: Wu, Xiaoyu, Wu, Guannan, Wu, Zhenfeng, Yao, Xuequan, Li, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800058/
https://www.ncbi.nlm.nih.gov/pubmed/26947878
http://dx.doi.org/10.1016/j.tranon.2015.11.005
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author Wu, Xiaoyu
Wu, Guannan
Wu, Zhenfeng
Yao, Xuequan
Li, Gang
author_facet Wu, Xiaoyu
Wu, Guannan
Wu, Zhenfeng
Yao, Xuequan
Li, Gang
author_sort Wu, Xiaoyu
collection PubMed
description MiR-200a has been reported to be able to suppress the epithelial-mesenchymal transition process in pancreatic cancer stem cells, suggesting that miR-200a could suppress the metastasis of pancreatic ductal adenocarcinoma (PDAC). However, its role in proliferation and metastasis of PDAC and the underlying mechanism by which miR-200a works in PDAC have not been elucidated. In our study, we for the first time identified that DEK gene is a direct downstream target of miR-200a. It was found that overexpression of miR-200a decreased DEK expression, suppressing the proliferation, migration, and invasion of PDAC cells. Meanwhile, knockdown of miR-200a can increase DEK level, promoting the proliferation, migration, and invasion of PDAC cells. Our study demonstrated that miR-200a suppresses the metastasis in pancreatic PDAC through downregulation of DEK, suggesting that miR-200a may be used as a novel potential marker in prediction of metastasis of PDAC.
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spelling pubmed-48000582016-04-05 MiR-200a Suppresses the Proliferation and Metastasis in Pancreatic Ductal Adenocarcinoma through Downregulation of DEK Gene() Wu, Xiaoyu Wu, Guannan Wu, Zhenfeng Yao, Xuequan Li, Gang Transl Oncol Original article MiR-200a has been reported to be able to suppress the epithelial-mesenchymal transition process in pancreatic cancer stem cells, suggesting that miR-200a could suppress the metastasis of pancreatic ductal adenocarcinoma (PDAC). However, its role in proliferation and metastasis of PDAC and the underlying mechanism by which miR-200a works in PDAC have not been elucidated. In our study, we for the first time identified that DEK gene is a direct downstream target of miR-200a. It was found that overexpression of miR-200a decreased DEK expression, suppressing the proliferation, migration, and invasion of PDAC cells. Meanwhile, knockdown of miR-200a can increase DEK level, promoting the proliferation, migration, and invasion of PDAC cells. Our study demonstrated that miR-200a suppresses the metastasis in pancreatic PDAC through downregulation of DEK, suggesting that miR-200a may be used as a novel potential marker in prediction of metastasis of PDAC. Neoplasia Press 2016-03-03 /pmc/articles/PMC4800058/ /pubmed/26947878 http://dx.doi.org/10.1016/j.tranon.2015.11.005 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original article
Wu, Xiaoyu
Wu, Guannan
Wu, Zhenfeng
Yao, Xuequan
Li, Gang
MiR-200a Suppresses the Proliferation and Metastasis in Pancreatic Ductal Adenocarcinoma through Downregulation of DEK Gene()
title MiR-200a Suppresses the Proliferation and Metastasis in Pancreatic Ductal Adenocarcinoma through Downregulation of DEK Gene()
title_full MiR-200a Suppresses the Proliferation and Metastasis in Pancreatic Ductal Adenocarcinoma through Downregulation of DEK Gene()
title_fullStr MiR-200a Suppresses the Proliferation and Metastasis in Pancreatic Ductal Adenocarcinoma through Downregulation of DEK Gene()
title_full_unstemmed MiR-200a Suppresses the Proliferation and Metastasis in Pancreatic Ductal Adenocarcinoma through Downregulation of DEK Gene()
title_short MiR-200a Suppresses the Proliferation and Metastasis in Pancreatic Ductal Adenocarcinoma through Downregulation of DEK Gene()
title_sort mir-200a suppresses the proliferation and metastasis in pancreatic ductal adenocarcinoma through downregulation of dek gene()
topic Original article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800058/
https://www.ncbi.nlm.nih.gov/pubmed/26947878
http://dx.doi.org/10.1016/j.tranon.2015.11.005
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