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Prehospital antiplatelet use and functional status on admission of patients with non-haemorrhagic moyamoya disease: a nationwide retrospective cohort study (J-ASPECT study)

OBJECTIVES: To elucidate the association between antiplatelet use in patients with non-haemorrhagic moyamoya disease before hospital admission and good functional status on admission in Japan. DESIGN: Retrospective, multicentre, non-randomised, observational study. SETTING: Nationwide registry data...

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Autores principales: Onozuka, Daisuke, Hagihara, Akihito, Nishimura, Kunihiro, Kada, Akiko, Nakagawara, Jyoji, Ogasawara, Kuniaki, Ono, Junichi, Shiokawa, Yoshiaki, Aruga, Toru, Miyachi, Shigeru, Nagata, Izumi, Toyoda, Kazunori, Matsuda, Shinya, Suzuki, Akifumi, Kataoka, Hiroharu, Nakamura, Fumiaki, Kamitani, Satoru, Nishimura, Ataru, Kurogi, Ryota, Sayama, Tetsuro, Iihara, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800148/
https://www.ncbi.nlm.nih.gov/pubmed/27008684
http://dx.doi.org/10.1136/bmjopen-2015-009942
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author Onozuka, Daisuke
Hagihara, Akihito
Nishimura, Kunihiro
Kada, Akiko
Nakagawara, Jyoji
Ogasawara, Kuniaki
Ono, Junichi
Shiokawa, Yoshiaki
Aruga, Toru
Miyachi, Shigeru
Nagata, Izumi
Toyoda, Kazunori
Matsuda, Shinya
Suzuki, Akifumi
Kataoka, Hiroharu
Nakamura, Fumiaki
Kamitani, Satoru
Nishimura, Ataru
Kurogi, Ryota
Sayama, Tetsuro
Iihara, Koji
author_facet Onozuka, Daisuke
Hagihara, Akihito
Nishimura, Kunihiro
Kada, Akiko
Nakagawara, Jyoji
Ogasawara, Kuniaki
Ono, Junichi
Shiokawa, Yoshiaki
Aruga, Toru
Miyachi, Shigeru
Nagata, Izumi
Toyoda, Kazunori
Matsuda, Shinya
Suzuki, Akifumi
Kataoka, Hiroharu
Nakamura, Fumiaki
Kamitani, Satoru
Nishimura, Ataru
Kurogi, Ryota
Sayama, Tetsuro
Iihara, Koji
author_sort Onozuka, Daisuke
collection PubMed
description OBJECTIVES: To elucidate the association between antiplatelet use in patients with non-haemorrhagic moyamoya disease before hospital admission and good functional status on admission in Japan. DESIGN: Retrospective, multicentre, non-randomised, observational study. SETTING: Nationwide registry data in Japan. PARTICIPANTS: A total of 1925 patients with non-haemorrhagic moyamoya disease admitted between 1 April 2012 and 31 March 2014 in Japan. MAIN OUTCOME MEASURE: We performed propensity score-matched analysis to examine the association between prehospital antiplatelet use and no significant disability on hospital admission, as defined by a modified Rankin Scale score of 0 or 1. RESULTS: Propensity-matched patients who received prehospital antiplatelet drugs were associated with a good outcome on hospital admission (OR adjusted for all covariates, 3.82; 95% CI 1.22 to 11.99) compared with those who did not receive antiplatelet drugs prior to hospital admission. CONCLUSIONS: Prehospital antiplatelet use was significantly associated with good functional status on hospital admission among patients with non-haemorrhagic moyamoya disease in Japan. Our results suggest that prehospital antiplatelet use should be considered when evaluating outcomes of patients with non-haemorrhagic moyamoya disease.
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spelling pubmed-48001482016-03-29 Prehospital antiplatelet use and functional status on admission of patients with non-haemorrhagic moyamoya disease: a nationwide retrospective cohort study (J-ASPECT study) Onozuka, Daisuke Hagihara, Akihito Nishimura, Kunihiro Kada, Akiko Nakagawara, Jyoji Ogasawara, Kuniaki Ono, Junichi Shiokawa, Yoshiaki Aruga, Toru Miyachi, Shigeru Nagata, Izumi Toyoda, Kazunori Matsuda, Shinya Suzuki, Akifumi Kataoka, Hiroharu Nakamura, Fumiaki Kamitani, Satoru Nishimura, Ataru Kurogi, Ryota Sayama, Tetsuro Iihara, Koji BMJ Open Epidemiology OBJECTIVES: To elucidate the association between antiplatelet use in patients with non-haemorrhagic moyamoya disease before hospital admission and good functional status on admission in Japan. DESIGN: Retrospective, multicentre, non-randomised, observational study. SETTING: Nationwide registry data in Japan. PARTICIPANTS: A total of 1925 patients with non-haemorrhagic moyamoya disease admitted between 1 April 2012 and 31 March 2014 in Japan. MAIN OUTCOME MEASURE: We performed propensity score-matched analysis to examine the association between prehospital antiplatelet use and no significant disability on hospital admission, as defined by a modified Rankin Scale score of 0 or 1. RESULTS: Propensity-matched patients who received prehospital antiplatelet drugs were associated with a good outcome on hospital admission (OR adjusted for all covariates, 3.82; 95% CI 1.22 to 11.99) compared with those who did not receive antiplatelet drugs prior to hospital admission. CONCLUSIONS: Prehospital antiplatelet use was significantly associated with good functional status on hospital admission among patients with non-haemorrhagic moyamoya disease in Japan. Our results suggest that prehospital antiplatelet use should be considered when evaluating outcomes of patients with non-haemorrhagic moyamoya disease. BMJ Publishing Group 2016-03-15 /pmc/articles/PMC4800148/ /pubmed/27008684 http://dx.doi.org/10.1136/bmjopen-2015-009942 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Epidemiology
Onozuka, Daisuke
Hagihara, Akihito
Nishimura, Kunihiro
Kada, Akiko
Nakagawara, Jyoji
Ogasawara, Kuniaki
Ono, Junichi
Shiokawa, Yoshiaki
Aruga, Toru
Miyachi, Shigeru
Nagata, Izumi
Toyoda, Kazunori
Matsuda, Shinya
Suzuki, Akifumi
Kataoka, Hiroharu
Nakamura, Fumiaki
Kamitani, Satoru
Nishimura, Ataru
Kurogi, Ryota
Sayama, Tetsuro
Iihara, Koji
Prehospital antiplatelet use and functional status on admission of patients with non-haemorrhagic moyamoya disease: a nationwide retrospective cohort study (J-ASPECT study)
title Prehospital antiplatelet use and functional status on admission of patients with non-haemorrhagic moyamoya disease: a nationwide retrospective cohort study (J-ASPECT study)
title_full Prehospital antiplatelet use and functional status on admission of patients with non-haemorrhagic moyamoya disease: a nationwide retrospective cohort study (J-ASPECT study)
title_fullStr Prehospital antiplatelet use and functional status on admission of patients with non-haemorrhagic moyamoya disease: a nationwide retrospective cohort study (J-ASPECT study)
title_full_unstemmed Prehospital antiplatelet use and functional status on admission of patients with non-haemorrhagic moyamoya disease: a nationwide retrospective cohort study (J-ASPECT study)
title_short Prehospital antiplatelet use and functional status on admission of patients with non-haemorrhagic moyamoya disease: a nationwide retrospective cohort study (J-ASPECT study)
title_sort prehospital antiplatelet use and functional status on admission of patients with non-haemorrhagic moyamoya disease: a nationwide retrospective cohort study (j-aspect study)
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800148/
https://www.ncbi.nlm.nih.gov/pubmed/27008684
http://dx.doi.org/10.1136/bmjopen-2015-009942
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