The Homophilic Domain – An Immunological Archetype

The homophilic potential emerges as an important biological principle to boost the potency of immunoglobulins. Since homophilic antibodies in human and mouse sera exist prior environmental exposure, they are part of the natural antibody repertoire. Nevertheless, hemophilic properties are also identi...

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Autores principales: Kohler, Heinz, Bayry, Jagadeesh, Kaveri, Srinivas V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800165/
https://www.ncbi.nlm.nih.gov/pubmed/27047493
http://dx.doi.org/10.3389/fimmu.2016.00106
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author Kohler, Heinz
Bayry, Jagadeesh
Kaveri, Srinivas V.
author_facet Kohler, Heinz
Bayry, Jagadeesh
Kaveri, Srinivas V.
author_sort Kohler, Heinz
collection PubMed
description The homophilic potential emerges as an important biological principle to boost the potency of immunoglobulins. Since homophilic antibodies in human and mouse sera exist prior environmental exposure, they are part of the natural antibody repertoire. Nevertheless, hemophilic properties are also identified in induced antibody repertoire. The use of homophilicity of antibodies in the adaptive immunity signifies an archetypic antibody structure. The unique feature of homophilicity in the antibody repertoire also highlights an important mechanism to boost the antibody potency to protect against infection and atherosclerosis as well to treat cancer patients.
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spelling pubmed-48001652016-04-04 The Homophilic Domain – An Immunological Archetype Kohler, Heinz Bayry, Jagadeesh Kaveri, Srinivas V. Front Immunol Immunology The homophilic potential emerges as an important biological principle to boost the potency of immunoglobulins. Since homophilic antibodies in human and mouse sera exist prior environmental exposure, they are part of the natural antibody repertoire. Nevertheless, hemophilic properties are also identified in induced antibody repertoire. The use of homophilicity of antibodies in the adaptive immunity signifies an archetypic antibody structure. The unique feature of homophilicity in the antibody repertoire also highlights an important mechanism to boost the antibody potency to protect against infection and atherosclerosis as well to treat cancer patients. Frontiers Media S.A. 2016-03-21 /pmc/articles/PMC4800165/ /pubmed/27047493 http://dx.doi.org/10.3389/fimmu.2016.00106 Text en Copyright © 2016 Kohler, Bayry and Kaveri. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Kohler, Heinz
Bayry, Jagadeesh
Kaveri, Srinivas V.
The Homophilic Domain – An Immunological Archetype
title The Homophilic Domain – An Immunological Archetype
title_full The Homophilic Domain – An Immunological Archetype
title_fullStr The Homophilic Domain – An Immunological Archetype
title_full_unstemmed The Homophilic Domain – An Immunological Archetype
title_short The Homophilic Domain – An Immunological Archetype
title_sort homophilic domain – an immunological archetype
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800165/
https://www.ncbi.nlm.nih.gov/pubmed/27047493
http://dx.doi.org/10.3389/fimmu.2016.00106
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