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Periodic forces trigger knot untying during translocation of knotted proteins
Proteins need to be unfolded when translocated through the pores in mitochondrial and other cellular membranes. Knotted proteins, however, might get stuck during this process, jamming the pore, since the diameter of the pore is smaller than the size of maximally tightened knot. The jamming probabili...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800218/ https://www.ncbi.nlm.nih.gov/pubmed/26996878 http://dx.doi.org/10.1038/srep21702 |