Ubiquitin-like modifier FAT10 attenuates RIG-I mediated antiviral signaling by segregating activated RIG-I from its signaling platform

RIG-I is a key cytosolic RNA sensor that mediates innate immune defense against RNA virus. Aberrant RIG-I activity leads to severe pathological states such as autosomal dominant multi-system disorder, inflammatory myophathies and dermatomyositis. Therefore, identification of regulators that ensure e...

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Detalles Bibliográficos
Autores principales: Nguyen, Nhung T.H., Now, Hesung, Kim, Woo-Jong, Kim, Nari, Yoo, Joo-Yeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800306/
https://www.ncbi.nlm.nih.gov/pubmed/26996158
http://dx.doi.org/10.1038/srep23377

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