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High-Sensitivity C-Reactive Protein Can Reflect Small Airway Obstruction in Childhood Asthma
PURPOSE: High-sensitivity assays enabled the identification of C-reactive protein (hs-CRP) at levels that were previously undetectable. We aimed to determine if hs-CRP could reflect airway inflammation in children, by comparing hs-CRP with spirometry and impulse oscillometry (IOS) parameters and sym...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Yonsei University College of Medicine
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800360/ https://www.ncbi.nlm.nih.gov/pubmed/26996570 http://dx.doi.org/10.3349/ymj.2016.57.3.690 |
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author | Ko, A Ra Kim, Yoon Hee Sol, In Suk Kim, Min Jung Yoon, Seo Hee Kim, Kyung Won Kim, Kyu-Earn |
author_facet | Ko, A Ra Kim, Yoon Hee Sol, In Suk Kim, Min Jung Yoon, Seo Hee Kim, Kyung Won Kim, Kyu-Earn |
author_sort | Ko, A Ra |
collection | PubMed |
description | PURPOSE: High-sensitivity assays enabled the identification of C-reactive protein (hs-CRP) at levels that were previously undetectable. We aimed to determine if hs-CRP could reflect airway inflammation in children, by comparing hs-CRP with spirometry and impulse oscillometry (IOS) parameters and symptomatic severities. MATERIALS AND METHODS: A total of 276 asthmatic children who visited Severance Children's Hospital from 2012–2014 were enrolled. Serum hs-CRP and pulmonary function tests were performed on the same day. Patients were divided into hs-CRP positive and negative groups (cut-off value, 3.0 mg/L). RESULTS: Of the 276 asthmatic children [median age 7.5 (5.9/10.1) years, 171 boys (62%)], 39 were hs-CRP positive and 237 were negative. Regarding spirometry parameters, we observed significant differences in maximum mid-expiratory flow, % predicted (FEF(25–75)) (p=0.010) between hs-CRP positive and negative groups, and a negative correlation between FEF(25–75) and hs-CRP. There were significant differences in the reactance area (AX) (p=0.046), difference between resistance at 5 Hz and 20 Hz (R5–R20) (p=0.027), resistance at 5 Hz, % predicted (R5) (p=0.027), and reactance at 5 Hz, % predicted (X5) (p=0.041) between hs-CRP positive and negative groups. There were significant positive correlations between hs-CRP and R5 (r=0.163, p=0.008), and X5 (r=0.164, p=0.007). Spirometry and IOS parameters had more relevance in patients with higher blood neutrophil levels in comparison to hs-CRP. CONCLUSION: Hs-CRP showed significant correlation with FEF(25–75), R5, and X5. It can reflect small airway obstruction in childhood asthma, and it is more prominent in neutrophil dominant inflammation. |
format | Online Article Text |
id | pubmed-4800360 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Yonsei University College of Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-48003602016-05-01 High-Sensitivity C-Reactive Protein Can Reflect Small Airway Obstruction in Childhood Asthma Ko, A Ra Kim, Yoon Hee Sol, In Suk Kim, Min Jung Yoon, Seo Hee Kim, Kyung Won Kim, Kyu-Earn Yonsei Med J Original Article PURPOSE: High-sensitivity assays enabled the identification of C-reactive protein (hs-CRP) at levels that were previously undetectable. We aimed to determine if hs-CRP could reflect airway inflammation in children, by comparing hs-CRP with spirometry and impulse oscillometry (IOS) parameters and symptomatic severities. MATERIALS AND METHODS: A total of 276 asthmatic children who visited Severance Children's Hospital from 2012–2014 were enrolled. Serum hs-CRP and pulmonary function tests were performed on the same day. Patients were divided into hs-CRP positive and negative groups (cut-off value, 3.0 mg/L). RESULTS: Of the 276 asthmatic children [median age 7.5 (5.9/10.1) years, 171 boys (62%)], 39 were hs-CRP positive and 237 were negative. Regarding spirometry parameters, we observed significant differences in maximum mid-expiratory flow, % predicted (FEF(25–75)) (p=0.010) between hs-CRP positive and negative groups, and a negative correlation between FEF(25–75) and hs-CRP. There were significant differences in the reactance area (AX) (p=0.046), difference between resistance at 5 Hz and 20 Hz (R5–R20) (p=0.027), resistance at 5 Hz, % predicted (R5) (p=0.027), and reactance at 5 Hz, % predicted (X5) (p=0.041) between hs-CRP positive and negative groups. There were significant positive correlations between hs-CRP and R5 (r=0.163, p=0.008), and X5 (r=0.164, p=0.007). Spirometry and IOS parameters had more relevance in patients with higher blood neutrophil levels in comparison to hs-CRP. CONCLUSION: Hs-CRP showed significant correlation with FEF(25–75), R5, and X5. It can reflect small airway obstruction in childhood asthma, and it is more prominent in neutrophil dominant inflammation. Yonsei University College of Medicine 2016-05-01 2016-03-15 /pmc/articles/PMC4800360/ /pubmed/26996570 http://dx.doi.org/10.3349/ymj.2016.57.3.690 Text en © Copyright: Yonsei University College of Medicine 2016 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Ko, A Ra Kim, Yoon Hee Sol, In Suk Kim, Min Jung Yoon, Seo Hee Kim, Kyung Won Kim, Kyu-Earn High-Sensitivity C-Reactive Protein Can Reflect Small Airway Obstruction in Childhood Asthma |
title | High-Sensitivity C-Reactive Protein Can Reflect Small Airway Obstruction in Childhood Asthma |
title_full | High-Sensitivity C-Reactive Protein Can Reflect Small Airway Obstruction in Childhood Asthma |
title_fullStr | High-Sensitivity C-Reactive Protein Can Reflect Small Airway Obstruction in Childhood Asthma |
title_full_unstemmed | High-Sensitivity C-Reactive Protein Can Reflect Small Airway Obstruction in Childhood Asthma |
title_short | High-Sensitivity C-Reactive Protein Can Reflect Small Airway Obstruction in Childhood Asthma |
title_sort | high-sensitivity c-reactive protein can reflect small airway obstruction in childhood asthma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800360/ https://www.ncbi.nlm.nih.gov/pubmed/26996570 http://dx.doi.org/10.3349/ymj.2016.57.3.690 |
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