Efficacy of Anti-NaV1.7 Antibody on the Sensory Nervous System in a Rat Model of Lumbar Intervertebral Disc Injury

PURPOSE: The pathophysiology of discogenic low back pain is not fully understood. Tetrodotoxin-sensitive voltage-gated sodium (NaV) channels are associated with primary sensory nerve transmission, and the NaV1.7 channel has emerged as an analgesic target. Previously, we found increased NaV1.7 expres...

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Detalles Bibliográficos
Autores principales: Nojima, Daisuke, Inage, Kazuhide, Sakuma, Yoshihiro, Sato, Jun, Orita, Sumihisa, Yamauchi, Kazuyo, Eguchi, Yawara, Ochiai, Nobuyasu, Kuniyoshi, Kazuki, Aoki, Yasuchika, Nakamura, Junichi, Miyagi, Masayuki, Suzuki, Miyako, Kubota, Gou, Sainoh, Takeshi, Fujimoto, Kazuki, Shiga, Yasuhiro, Abe, Koki, Kanamoto, Hirohito, Inoue, Gen, Takahashi, Kazuhisa, Ohtori, Seiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800367/
https://www.ncbi.nlm.nih.gov/pubmed/26996577
http://dx.doi.org/10.3349/ymj.2016.57.3.748

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