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Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids

[Image: see text] The misfolding and aggregation of proteins into amyloid fibrils characterizes many neurodegenerative disorders such as Parkinson’s and Alzheimer’s diseases. We report here a method, termed SAVE (single aggregate visualization by enhancement) imaging, for the ultrasensitive detectio...

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Detalles Bibliográficos
Autores principales:	Horrocks, Mathew H., Lee, Steven F., Gandhi, Sonia, Magdalinou, Nadia K., Chen, Serene W., Devine, Michael J., Tosatto, Laura, Kjaergaard, Magnus, Beckwith, Joseph S., Zetterberg, Henrik, Iljina, Marija, Cremades, Nunilo, Dobson, Christopher M., Wood, Nicholas W., Klenerman, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2016
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800427/ https://www.ncbi.nlm.nih.gov/pubmed/26800462 http://dx.doi.org/10.1021/acschemneuro.5b00324

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