Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease

Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with MGAS10750 revealed nonsynonymous polymorphisms in ropB and increased speB tran...

Descripción completa

Detalles Bibliográficos
Autores principales: Galloway-Peña, Jessica, Clement, Meredith E., Sharma Kuinkel, Batu K., Ruffin, Felicia, Flores, Anthony R., Levinson, Howard, Shelburne, Samuel A., Moore, Zack, Fowler, Vance G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800461/
https://www.ncbi.nlm.nih.gov/pubmed/27006966
http://dx.doi.org/10.1093/ofid/ofw042
Descripción
Sumario:Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with MGAS10750 revealed nonsynonymous polymorphisms in ropB and increased speB transcription. This study demonstrates the usefulness of whole-genome analyses for GAS outbreaks.

Ejemplares similares