Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease

Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with MGAS10750 revealed nonsynonymous polymorphisms in ropB and increased speB tran...

Descripción completa

Detalles Bibliográficos
Autores principales: Galloway-Peña, Jessica, Clement, Meredith E., Sharma Kuinkel, Batu K., Ruffin, Felicia, Flores, Anthony R., Levinson, Howard, Shelburne, Samuel A., Moore, Zack, Fowler, Vance G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800461/
https://www.ncbi.nlm.nih.gov/pubmed/27006966
http://dx.doi.org/10.1093/ofid/ofw042
_version_ 1782422491744960512
author Galloway-Peña, Jessica
Clement, Meredith E.
Sharma Kuinkel, Batu K.
Ruffin, Felicia
Flores, Anthony R.
Levinson, Howard
Shelburne, Samuel A.
Moore, Zack
Fowler, Vance G.
author_facet Galloway-Peña, Jessica
Clement, Meredith E.
Sharma Kuinkel, Batu K.
Ruffin, Felicia
Flores, Anthony R.
Levinson, Howard
Shelburne, Samuel A.
Moore, Zack
Fowler, Vance G.
author_sort Galloway-Peña, Jessica
collection PubMed
description Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with MGAS10750 revealed nonsynonymous polymorphisms in ropB and increased speB transcription. This study demonstrates the usefulness of whole-genome analyses for GAS outbreaks.
format Online
Article
Text
id pubmed-4800461
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-48004612016-03-22 Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease Galloway-Peña, Jessica Clement, Meredith E. Sharma Kuinkel, Batu K. Ruffin, Felicia Flores, Anthony R. Levinson, Howard Shelburne, Samuel A. Moore, Zack Fowler, Vance G. Open Forum Infect Dis Brief Reports Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with MGAS10750 revealed nonsynonymous polymorphisms in ropB and increased speB transcription. This study demonstrates the usefulness of whole-genome analyses for GAS outbreaks. Oxford University Press 2016-02-19 /pmc/articles/PMC4800461/ /pubmed/27006966 http://dx.doi.org/10.1093/ofid/ofw042 Text en © The Author 2016. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Reports
Galloway-Peña, Jessica
Clement, Meredith E.
Sharma Kuinkel, Batu K.
Ruffin, Felicia
Flores, Anthony R.
Levinson, Howard
Shelburne, Samuel A.
Moore, Zack
Fowler, Vance G.
Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease
title Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease
title_full Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease
title_fullStr Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease
title_full_unstemmed Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease
title_short Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease
title_sort application of whole-genome sequencing to an unusual outbreak of invasive group a streptococcal disease
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800461/
https://www.ncbi.nlm.nih.gov/pubmed/27006966
http://dx.doi.org/10.1093/ofid/ofw042
work_keys_str_mv AT gallowaypenajessica applicationofwholegenomesequencingtoanunusualoutbreakofinvasivegroupastreptococcaldisease
AT clementmeredithe applicationofwholegenomesequencingtoanunusualoutbreakofinvasivegroupastreptococcaldisease
AT sharmakuinkelbatuk applicationofwholegenomesequencingtoanunusualoutbreakofinvasivegroupastreptococcaldisease
AT ruffinfelicia applicationofwholegenomesequencingtoanunusualoutbreakofinvasivegroupastreptococcaldisease
AT floresanthonyr applicationofwholegenomesequencingtoanunusualoutbreakofinvasivegroupastreptococcaldisease
AT levinsonhoward applicationofwholegenomesequencingtoanunusualoutbreakofinvasivegroupastreptococcaldisease
AT shelburnesamuela applicationofwholegenomesequencingtoanunusualoutbreakofinvasivegroupastreptococcaldisease
AT moorezack applicationofwholegenomesequencingtoanunusualoutbreakofinvasivegroupastreptococcaldisease
AT fowlervanceg applicationofwholegenomesequencingtoanunusualoutbreakofinvasivegroupastreptococcaldisease

Ejemplares similares