Long-Term Control of Human Immunodeficiency Virus-1 Replication Despite Extensive Resistance to Current Antiretroviral Regimens: Clonal Analysis of Resistance Mutations in Proviral Deoxyribonucleic Acid

Archived resistance mutations compromise antiretroviral treatment. We have investigated 3 selected aviremic patients who had extensive historical resistance to their current regimen. All 3 patients underwent unstructured treatment interruptions associated to the re-emergence of wild-type virus befor...

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Autores principales: Stella-Ascariz, Natalia, Montejano, Rocio, Martin-Vicente, María, Mingorance, Jesús, Pérez-Valero, Ignacio, Bernardino, José I., Arribas, Jose R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800466/
https://www.ncbi.nlm.nih.gov/pubmed/27006965
http://dx.doi.org/10.1093/ofid/ofw041
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author Stella-Ascariz, Natalia
Montejano, Rocio
Martin-Vicente, María
Mingorance, Jesús
Pérez-Valero, Ignacio
Bernardino, José I.
Arribas, Jose R.
author_facet Stella-Ascariz, Natalia
Montejano, Rocio
Martin-Vicente, María
Mingorance, Jesús
Pérez-Valero, Ignacio
Bernardino, José I.
Arribas, Jose R.
author_sort Stella-Ascariz, Natalia
collection PubMed
description Archived resistance mutations compromise antiretroviral treatment. We have investigated 3 selected aviremic patients who had extensive historical resistance to their current regimen. All 3 patients underwent unstructured treatment interruptions associated to the re-emergence of wild-type virus before starting their current suppressive regimes. Almost all historical resistance mutations detected in plasma were found in circulating proviral deoxyribonucleic acid. None of the clones analyzed was fully resistant to the current antiretroviral regimen.
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spelling pubmed-48004662016-03-22 Long-Term Control of Human Immunodeficiency Virus-1 Replication Despite Extensive Resistance to Current Antiretroviral Regimens: Clonal Analysis of Resistance Mutations in Proviral Deoxyribonucleic Acid Stella-Ascariz, Natalia Montejano, Rocio Martin-Vicente, María Mingorance, Jesús Pérez-Valero, Ignacio Bernardino, José I. Arribas, Jose R. Open Forum Infect Dis Brief Reports Archived resistance mutations compromise antiretroviral treatment. We have investigated 3 selected aviremic patients who had extensive historical resistance to their current regimen. All 3 patients underwent unstructured treatment interruptions associated to the re-emergence of wild-type virus before starting their current suppressive regimes. Almost all historical resistance mutations detected in plasma were found in circulating proviral deoxyribonucleic acid. None of the clones analyzed was fully resistant to the current antiretroviral regimen. Oxford University Press 2016-02-19 /pmc/articles/PMC4800466/ /pubmed/27006965 http://dx.doi.org/10.1093/ofid/ofw041 Text en © The Author 2016. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Reports
Stella-Ascariz, Natalia
Montejano, Rocio
Martin-Vicente, María
Mingorance, Jesús
Pérez-Valero, Ignacio
Bernardino, José I.
Arribas, Jose R.
Long-Term Control of Human Immunodeficiency Virus-1 Replication Despite Extensive Resistance to Current Antiretroviral Regimens: Clonal Analysis of Resistance Mutations in Proviral Deoxyribonucleic Acid
title Long-Term Control of Human Immunodeficiency Virus-1 Replication Despite Extensive Resistance to Current Antiretroviral Regimens: Clonal Analysis of Resistance Mutations in Proviral Deoxyribonucleic Acid
title_full Long-Term Control of Human Immunodeficiency Virus-1 Replication Despite Extensive Resistance to Current Antiretroviral Regimens: Clonal Analysis of Resistance Mutations in Proviral Deoxyribonucleic Acid
title_fullStr Long-Term Control of Human Immunodeficiency Virus-1 Replication Despite Extensive Resistance to Current Antiretroviral Regimens: Clonal Analysis of Resistance Mutations in Proviral Deoxyribonucleic Acid
title_full_unstemmed Long-Term Control of Human Immunodeficiency Virus-1 Replication Despite Extensive Resistance to Current Antiretroviral Regimens: Clonal Analysis of Resistance Mutations in Proviral Deoxyribonucleic Acid
title_short Long-Term Control of Human Immunodeficiency Virus-1 Replication Despite Extensive Resistance to Current Antiretroviral Regimens: Clonal Analysis of Resistance Mutations in Proviral Deoxyribonucleic Acid
title_sort long-term control of human immunodeficiency virus-1 replication despite extensive resistance to current antiretroviral regimens: clonal analysis of resistance mutations in proviral deoxyribonucleic acid
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800466/
https://www.ncbi.nlm.nih.gov/pubmed/27006965
http://dx.doi.org/10.1093/ofid/ofw041
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