Acute Cryptococcal Immune Reconstitution Inflammatory Syndrome in a Patient on Natalizumab

Presented is the first case of acute immune reconstitution inflammatory syndrome (IRIS)-associated cryptococcal meningoencephalitis in a patient on natalizumab for multiple sclerosis. The patient developed acute cerebral edema after initiation of amphotericin B. We propose several mechanisms that ex...

Descripción completa

Detalles Bibliográficos
Autores principales: Gundacker, Nathan D., Jordan, Stephen J., Jones, Benjamin A., Drwiega, Joseph C., Pappas, Peter G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800467/
https://www.ncbi.nlm.nih.gov/pubmed/27006962
http://dx.doi.org/10.1093/ofid/ofw038
Descripción
Sumario:Presented is the first case of acute immune reconstitution inflammatory syndrome (IRIS)-associated cryptococcal meningoencephalitis in a patient on natalizumab for multiple sclerosis. The patient developed acute cerebral edema after initiation of amphotericin B. We propose several mechanisms that explain the acuity of IRIS in this specific patient population and suggest possible therapies.

Ejemplares similares