Acute Cryptococcal Immune Reconstitution Inflammatory Syndrome in a Patient on Natalizumab

Presented is the first case of acute immune reconstitution inflammatory syndrome (IRIS)-associated cryptococcal meningoencephalitis in a patient on natalizumab for multiple sclerosis. The patient developed acute cerebral edema after initiation of amphotericin B. We propose several mechanisms that ex...

Descripción completa

Detalles Bibliográficos
Autores principales: Gundacker, Nathan D., Jordan, Stephen J., Jones, Benjamin A., Drwiega, Joseph C., Pappas, Peter G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800467/
https://www.ncbi.nlm.nih.gov/pubmed/27006962
http://dx.doi.org/10.1093/ofid/ofw038
_version_ 1782422493126983680
author Gundacker, Nathan D.
Jordan, Stephen J.
Jones, Benjamin A.
Drwiega, Joseph C.
Pappas, Peter G.
author_facet Gundacker, Nathan D.
Jordan, Stephen J.
Jones, Benjamin A.
Drwiega, Joseph C.
Pappas, Peter G.
author_sort Gundacker, Nathan D.
collection PubMed
description Presented is the first case of acute immune reconstitution inflammatory syndrome (IRIS)-associated cryptococcal meningoencephalitis in a patient on natalizumab for multiple sclerosis. The patient developed acute cerebral edema after initiation of amphotericin B. We propose several mechanisms that explain the acuity of IRIS in this specific patient population and suggest possible therapies.
format Online
Article
Text
id pubmed-4800467
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-48004672016-03-22 Acute Cryptococcal Immune Reconstitution Inflammatory Syndrome in a Patient on Natalizumab Gundacker, Nathan D. Jordan, Stephen J. Jones, Benjamin A. Drwiega, Joseph C. Pappas, Peter G. Open Forum Infect Dis Brief Reports Presented is the first case of acute immune reconstitution inflammatory syndrome (IRIS)-associated cryptococcal meningoencephalitis in a patient on natalizumab for multiple sclerosis. The patient developed acute cerebral edema after initiation of amphotericin B. We propose several mechanisms that explain the acuity of IRIS in this specific patient population and suggest possible therapies. Oxford University Press 2016-02-17 /pmc/articles/PMC4800467/ /pubmed/27006962 http://dx.doi.org/10.1093/ofid/ofw038 Text en © The Author 2016. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Reports
Gundacker, Nathan D.
Jordan, Stephen J.
Jones, Benjamin A.
Drwiega, Joseph C.
Pappas, Peter G.
Acute Cryptococcal Immune Reconstitution Inflammatory Syndrome in a Patient on Natalizumab
title Acute Cryptococcal Immune Reconstitution Inflammatory Syndrome in a Patient on Natalizumab
title_full Acute Cryptococcal Immune Reconstitution Inflammatory Syndrome in a Patient on Natalizumab
title_fullStr Acute Cryptococcal Immune Reconstitution Inflammatory Syndrome in a Patient on Natalizumab
title_full_unstemmed Acute Cryptococcal Immune Reconstitution Inflammatory Syndrome in a Patient on Natalizumab
title_short Acute Cryptococcal Immune Reconstitution Inflammatory Syndrome in a Patient on Natalizumab
title_sort acute cryptococcal immune reconstitution inflammatory syndrome in a patient on natalizumab
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800467/
https://www.ncbi.nlm.nih.gov/pubmed/27006962
http://dx.doi.org/10.1093/ofid/ofw038
work_keys_str_mv AT gundackernathand acutecryptococcalimmunereconstitutioninflammatorysyndromeinapatientonnatalizumab
AT jordanstephenj acutecryptococcalimmunereconstitutioninflammatorysyndromeinapatientonnatalizumab
AT jonesbenjamina acutecryptococcalimmunereconstitutioninflammatorysyndromeinapatientonnatalizumab
AT drwiegajosephc acutecryptococcalimmunereconstitutioninflammatorysyndromeinapatientonnatalizumab
AT pappaspeterg acutecryptococcalimmunereconstitutioninflammatorysyndromeinapatientonnatalizumab

Ejemplares similares