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Associations between nitric oxide synthase 3 gene polymorphisms and preeclampsia risk: a meta-analysis

Previous studies have examined the role of three NOS3 gene polymorphisms [G894T, T-786C, and the variable number of tandem repeats 4b/a (VNTR 4b/a)] in the susceptibility to preeclampsia with inconclusive findings. We therefore conducted an updated meta-analysis by including more studies. The most a...

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Autores principales: Zeng, Fangfang, Zhu, Sui, Wong, Martin Chi-Sang, Yang, Zuyao, Tang, Jinling, Li, Keshen, Su, Xuefen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800677/
https://www.ncbi.nlm.nih.gov/pubmed/26997284
http://dx.doi.org/10.1038/srep23407
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author Zeng, Fangfang
Zhu, Sui
Wong, Martin Chi-Sang
Yang, Zuyao
Tang, Jinling
Li, Keshen
Su, Xuefen
author_facet Zeng, Fangfang
Zhu, Sui
Wong, Martin Chi-Sang
Yang, Zuyao
Tang, Jinling
Li, Keshen
Su, Xuefen
author_sort Zeng, Fangfang
collection PubMed
description Previous studies have examined the role of three NOS3 gene polymorphisms [G894T, T-786C, and the variable number of tandem repeats 4b/a (VNTR 4b/a)] in the susceptibility to preeclampsia with inconclusive findings. We therefore conducted an updated meta-analysis by including more studies. The most appropriate genetic model was chosen for each polymorphism by using a well-established method. Pooled results indicated that, compared with the GT + GG genotype, the TT genotype of G894T was associated with an increased risk of preeclampsia (odds ratio (OR) = 1.46; 95% confidence interval (CI) = 1.21–1.77, P < 0.001; I(2) = 40.2%). The CC genotype of T-786C was also associated with a higher risk of preeclampsia (OR = 1.30; 95% CI = 1.07–1.58, P = 0.034; I(2) = 46.9%) than the CT + TT genotype. No association was found for VNTR 4b/a. Stratified analysis indicated that the increased risk was evident for high-quality studies both for G894T and T-786C, and for studies conducted among Caucasians and Africans for T-786C. However, the increased risk for T-786C among Africans needs further confirmation due to the high probability of false-positive reports. Our results suggested that G894T and T-786C polymorphisms, but not VNTR 4b/a, were associated with an increased risk of preeclampsia.
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spelling pubmed-48006772016-03-22 Associations between nitric oxide synthase 3 gene polymorphisms and preeclampsia risk: a meta-analysis Zeng, Fangfang Zhu, Sui Wong, Martin Chi-Sang Yang, Zuyao Tang, Jinling Li, Keshen Su, Xuefen Sci Rep Article Previous studies have examined the role of three NOS3 gene polymorphisms [G894T, T-786C, and the variable number of tandem repeats 4b/a (VNTR 4b/a)] in the susceptibility to preeclampsia with inconclusive findings. We therefore conducted an updated meta-analysis by including more studies. The most appropriate genetic model was chosen for each polymorphism by using a well-established method. Pooled results indicated that, compared with the GT + GG genotype, the TT genotype of G894T was associated with an increased risk of preeclampsia (odds ratio (OR) = 1.46; 95% confidence interval (CI) = 1.21–1.77, P < 0.001; I(2) = 40.2%). The CC genotype of T-786C was also associated with a higher risk of preeclampsia (OR = 1.30; 95% CI = 1.07–1.58, P = 0.034; I(2) = 46.9%) than the CT + TT genotype. No association was found for VNTR 4b/a. Stratified analysis indicated that the increased risk was evident for high-quality studies both for G894T and T-786C, and for studies conducted among Caucasians and Africans for T-786C. However, the increased risk for T-786C among Africans needs further confirmation due to the high probability of false-positive reports. Our results suggested that G894T and T-786C polymorphisms, but not VNTR 4b/a, were associated with an increased risk of preeclampsia. Nature Publishing Group 2016-03-21 /pmc/articles/PMC4800677/ /pubmed/26997284 http://dx.doi.org/10.1038/srep23407 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zeng, Fangfang
Zhu, Sui
Wong, Martin Chi-Sang
Yang, Zuyao
Tang, Jinling
Li, Keshen
Su, Xuefen
Associations between nitric oxide synthase 3 gene polymorphisms and preeclampsia risk: a meta-analysis
title Associations between nitric oxide synthase 3 gene polymorphisms and preeclampsia risk: a meta-analysis
title_full Associations between nitric oxide synthase 3 gene polymorphisms and preeclampsia risk: a meta-analysis
title_fullStr Associations between nitric oxide synthase 3 gene polymorphisms and preeclampsia risk: a meta-analysis
title_full_unstemmed Associations between nitric oxide synthase 3 gene polymorphisms and preeclampsia risk: a meta-analysis
title_short Associations between nitric oxide synthase 3 gene polymorphisms and preeclampsia risk: a meta-analysis
title_sort associations between nitric oxide synthase 3 gene polymorphisms and preeclampsia risk: a meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800677/
https://www.ncbi.nlm.nih.gov/pubmed/26997284
http://dx.doi.org/10.1038/srep23407
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