Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation

Histone methylation regulates DNA repair. However, the mechanisms that underlie the regulation of histone methylation during this repair remain to be further defined. Here, we show that ionizing radiation (IR) induces DNA-PK-dependent phosphorylation of nuclear fumarase at T236, which leads to an in...

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Detalles Bibliográficos
Autores principales: Jiang, Yuhui, Qian, Xu, Shen, Jianfeng, Wang, Yugang, Li, Xinjian, Liu, Rui, Xia, Yan, Chen, Qianming, Peng, Guang, Lin, Shiaw-Yih, Lu, Zhimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800990/
https://www.ncbi.nlm.nih.gov/pubmed/26237645
http://dx.doi.org/10.1038/ncb3209

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