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A new view of transcriptome complexity and regulation through the lens of local splicing variations
Alternative splicing (AS) can critically affect gene function and disease, yet mapping splicing variations remains a challenge. Here, we propose a new approach to define and quantify mRNA splicing in units of local splicing variations (LSVs). LSVs capture previously defined types of alternative spli...
Autores principales: | Vaquero-Garcia, Jorge, Barrera, Alejandro, Gazzara, Matthew R, González-Vallinas, Juan, Lahens, Nicholas F, Hogenesch, John B, Lynch, Kristen W, Barash, Yoseph |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801060/ https://www.ncbi.nlm.nih.gov/pubmed/26829591 http://dx.doi.org/10.7554/eLife.11752 |
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