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Nontubulation Repair of Peripheral Nerve Gap Using Heparin/Alginate Gel Combined with b-FGF

All artificial nerve grafts have a tubular structure, and they guide axonal regrowth through the tube from the proximal side toward the peripheral side. Based on the results of our experimental study using animals, we used alginate gel without a tubular structure as an artificial nerve graft for dig...

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Detalles Bibliográficos
Autores principales: Suzuki, Yoshihisa, Ishikawa, Namiko, Tanihara, Masao, Saito, Susumu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801089/
https://www.ncbi.nlm.nih.gov/pubmed/27104099
http://dx.doi.org/10.1097/GOX.0000000000000581
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author Suzuki, Yoshihisa
Ishikawa, Namiko
Tanihara, Masao
Saito, Susumu
author_facet Suzuki, Yoshihisa
Ishikawa, Namiko
Tanihara, Masao
Saito, Susumu
author_sort Suzuki, Yoshihisa
collection PubMed
description All artificial nerve grafts have a tubular structure, and they guide axonal regrowth through the tube from the proximal side toward the peripheral side. Based on the results of our experimental study using animals, we used alginate gel without a tubular structure as an artificial nerve graft for digital nerve repair and evaluated peripheral nerve regeneration. In 2 patients, a gap due to digital nerve injury was bridged with controlled-release heparin/alginate gel combined with basic fibroblast growth factor, and restoration of the sensory function was serially evaluated. In both patients, Tinel’s sign appeared 3–4 weeks after the operation, and sensory recovery to the fingertip was achieved at 6 months postoperatively. Our results suggest that even gel without a tubular structure provides a site for peripheral nerve regeneration.
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spelling pubmed-48010892016-04-21 Nontubulation Repair of Peripheral Nerve Gap Using Heparin/Alginate Gel Combined with b-FGF Suzuki, Yoshihisa Ishikawa, Namiko Tanihara, Masao Saito, Susumu Plast Reconstr Surg Glob Open Case Report All artificial nerve grafts have a tubular structure, and they guide axonal regrowth through the tube from the proximal side toward the peripheral side. Based on the results of our experimental study using animals, we used alginate gel without a tubular structure as an artificial nerve graft for digital nerve repair and evaluated peripheral nerve regeneration. In 2 patients, a gap due to digital nerve injury was bridged with controlled-release heparin/alginate gel combined with basic fibroblast growth factor, and restoration of the sensory function was serially evaluated. In both patients, Tinel’s sign appeared 3–4 weeks after the operation, and sensory recovery to the fingertip was achieved at 6 months postoperatively. Our results suggest that even gel without a tubular structure provides a site for peripheral nerve regeneration. Wolters Kluwer Health 2016-01-27 /pmc/articles/PMC4801089/ /pubmed/27104099 http://dx.doi.org/10.1097/GOX.0000000000000581 Text en Copyright © 2016 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
spellingShingle Case Report
Suzuki, Yoshihisa
Ishikawa, Namiko
Tanihara, Masao
Saito, Susumu
Nontubulation Repair of Peripheral Nerve Gap Using Heparin/Alginate Gel Combined with b-FGF
title Nontubulation Repair of Peripheral Nerve Gap Using Heparin/Alginate Gel Combined with b-FGF
title_full Nontubulation Repair of Peripheral Nerve Gap Using Heparin/Alginate Gel Combined with b-FGF
title_fullStr Nontubulation Repair of Peripheral Nerve Gap Using Heparin/Alginate Gel Combined with b-FGF
title_full_unstemmed Nontubulation Repair of Peripheral Nerve Gap Using Heparin/Alginate Gel Combined with b-FGF
title_short Nontubulation Repair of Peripheral Nerve Gap Using Heparin/Alginate Gel Combined with b-FGF
title_sort nontubulation repair of peripheral nerve gap using heparin/alginate gel combined with b-fgf
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801089/
https://www.ncbi.nlm.nih.gov/pubmed/27104099
http://dx.doi.org/10.1097/GOX.0000000000000581
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