Cargando…

Selective CDK7 inhibition with BS-181 suppresses cell proliferation and induces cell cycle arrest and apoptosis in gastric cancer

Cyclin-dependent kinase (CDK) family members have been considered as attractive therapeutic targets for cancer. In this study, we aim to investigate the anticancer effects of a selective CDK7 inhibitor, BS-181, in gastric cancer (GC) cell line. Human GC cells (BGC823) were cultured with or without B...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Bo-Yong, Liu, Quan-Yan, Cao, Jun, Chen, Ji-Wei, Liu, Zhi-Su
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801149/ https://www.ncbi.nlm.nih.gov/pubmed/27042010 http://dx.doi.org/10.2147/DDDT.S86317

Ejemplares similares

G(1) Cell Cycle Arrest and Extrinsic Apoptotic Mechanisms Underlying the Anti-Leukemic Activity of CDK7 Inhibitor BS-181
por: Park, Shin Young, et al.
Publicado: (2020)

CDK5 Knockdown inhibits proliferation and induces apoptosis and Cell Cycle Arrest in Human Glioblastoma
por: Zhou, Yan, et al.
Publicado: (2021)

Knockdown of MRPL42 suppresses glioma cell proliferation by inducing cell cycle arrest and apoptosis
por: Hao, Chunyan, et al.
Publicado: (2018)

Glycyrrhizic Acid Inhibits Proliferation of Gastric Cancer Cells by Inducing Cell Cycle Arrest and Apoptosis
por: Wang, Hao, et al.
Publicado: (2020)

REG γ knockdown suppresses proliferation by inducing apoptosis and cell cycle arrest in osteosarcoma
por: Yin, Zhiqiang, et al.
Publicado: (2020)

Resveratrol inhibits proliferation in human colorectal carcinoma cells by inducing G(1)/S-phase cell cycle arrest and apoptosis through caspase/cyclin-CDK pathways
por: LIU, BIN, et al.
Publicado: (2014)

Piperlongumine Suppresses Proliferation of Human Oral Squamous Cell Carcinoma through Cell Cycle Arrest, Apoptosis and Senescence
por: Chen, San-Yuan, et al.
Publicado: (2016)

Chinese Propolis Inhibits the Proliferation of Human Gastric Cancer Cells by Inducing Apoptosis and Cell Cycle Arrest
por: Jiang, Xia-sen, et al.
Publicado: (2020)

UBE2T silencing suppresses proliferation and induces cell cycle arrest and apoptosis in bladder cancer cells
por: Gong, Yan Qing, et al.
Publicado: (2016)

Diosmetin suppresses human prostate cancer cell proliferation through the induction of apoptosis and cell cycle arrest
por: Oak, Christine, et al.
Publicado: (2018)

Kaempferol Suppresses Proliferation and Induces Cell Cycle Arrest, Apoptosis, and DNA Damage in Breast Cancer Cells
por: Zhu, Li, et al.
Publicado: (2019)

Podofilox suppresses gastric cancer cell proliferation by regulating cell cycle arrest and the c-Myc/ATG10 axis
por: An, Juan, et al.
Publicado: (2021)

Silencing of MAP4K4 by short hairpin RNA suppresses proliferation, induces G1 cell cycle arrest and induces apoptosis in gastric cancer cells
por: LIU, YUAN-FEI, et al.
Publicado: (2016)

Sulforaphane-cysteine downregulates CDK4 /CDK6 and inhibits tubulin polymerization contributing to cell cycle arrest and apoptosis in human glioblastoma cells
por: Li, Juntao, et al.
Publicado: (2020)

Downregulation of SOX9 suppresses breast cancer cell proliferation and migration by regulating apoptosis and cell cycle arrest
por: Wang, Yu-Feng, et al.
Publicado: (2021)

Sugiol Suppresses the Proliferation of Human U87 Glioma Cells via Induction of Apoptosis and Cell Cycle Arrest
por: Alharthy, Saif A., et al.
Publicado: (2022)

Mitochondrion-Targeted NIR Therapeutic Agent Suppresses Melanoma by Inducing Apoptosis and Cell Cycle Arrest via E2F/Cyclin/CDK Pathway
por: Sun, Changzhen, et al.
Publicado: (2022)

The CDK inhibitor AT7519 inhibits human glioblastoma cell growth by inducing apoptosis, pyroptosis and cell cycle arrest
por: Zhao, Wenpeng, et al.
Publicado: (2023)

Down-Regulation of AP-4 Inhibits Proliferation, Induces Cell Cycle Arrest and Promotes Apoptosis in Human Gastric Cancer Cells
por: Liu, Xinghua, et al.
Publicado: (2012)

High temperature suppressed SSC self-renewal through S phase cell cycle arrest but not apoptosis
por: Wang, Jia, et al.
Publicado: (2019)

GNA14 silencing suppresses the proliferation of endometrial carcinoma cells through inducing apoptosis and G(2)/M cell cycle arrest
por: Wang, Jing, et al.
Publicado: (2018)

Semisynthetic aurones A14 protects against T-cell acute lymphoblastic leukemia via suppressing proliferation and inducing cell cycle arrest with apoptosis
por: Wang, Meng, et al.
Publicado: (2022)

Cimiside E arrests cell cycle and induces cell apoptosis in gastric cancer cells
por: Guo, Lian Yu, et al.
Publicado: (2009)

MLN4924 suppresses neddylation and induces cell cycle arrest, senescence, and apoptosis in human osteosarcoma
por: Zhang, Yi, et al.
Publicado: (2016)

CMPD1 inhibited human gastric cancer cell proliferation by inducing apoptosis and G2/M cell cycle arrest
por: Li, Yu, et al.
Publicado: (2018)

Neuronal pentraxin II (NPTX2) hypermethylation promotes cell proliferation but inhibits cell cycle arrest and apoptosis in gastric cancer cells by suppressing the p53 signaling pathway
por: Xu, Guofeng, et al.
Publicado: (2021)

COPB2 suppresses cell proliferation and induces cell cycle arrest in human colon cancer by regulating cell cycle-related proteins
por: Wang, Yan, et al.
Publicado: (2018)

Depletion of thymopoietin inhibits proliferation and induces cell cycle arrest/apoptosis in glioblastoma cells
por: Zhang, Lin, et al.
Publicado: (2016)

CRM1 inhibitor S109 suppresses cell proliferation and induces cell cycle arrest in renal cancer cells
por: Liu, Xuejiao, et al.
Publicado: (2016)

Cannabidiol Induces Cell Cycle Arrest and Cell Apoptosis in Human Gastric Cancer SGC-7901 Cells
por: Zhang, Xin, et al.
Publicado: (2019)

O-desmethylangolensin inhibits the proliferation of human breast cancer MCF-7 cells by inducing apoptosis and promoting cell cycle arrest
por: CHOI, EUN JEONG, et al.
Publicado: (2013)

Flubendazole inhibits glioma proliferation by G2/M cell cycle arrest and pro-apoptosis
por: Zhou, Xumin, et al.
Publicado: (2018)

Diosmetin Inhibits Cell Proliferation, Induces Cell Apoptosis and Cell Cycle Arrest in Liver Cancer
por: Ma, Aiqing, et al.
Publicado: (2020)

ARV-771 Acts as an Inducer of Cell Cycle Arrest and Apoptosis to Suppress Hepatocellular Carcinoma Progression
por: Deng, Yuanfei, et al.
Publicado: (2022)

ZHX1 Inhibits Gastric Cancer Cell Growth through Inducing Cell-Cycle Arrest and Apoptosis
por: Ma, Xingjie, et al.
Publicado: (2016)

Astragalus Polysaccharide RAP Selectively Attenuates Paclitaxel-Induced Cytotoxicity Toward RAW 264.7 Cells by Reversing Cell Cycle Arrest and Apoptosis
por: Bao, Wan-Rong, et al.
Publicado: (2019)

MicroRNA-181a promotes cell proliferation and inhibits apoptosis in gastric cancer by targeting RASSF1A
por: Yu, Junhui, et al.
Publicado: (2018)

TBX3 knockdown suppresses the proliferation of hypopharyngeal carcinoma FaDu cells by inducing G1/S cell cycle arrest and apoptosis
por: Huang, Yongjiu, et al.
Publicado: (2020)

Adapalene Inhibits Prostate Cancer Cell Proliferation In Vitro and In Vivo by Inducing DNA Damage, S-phase Cell Cycle Arrest, and Apoptosis
por: Nong, Hai-bin, et al.
Publicado: (2022)

Selumetinib suppresses cell proliferation, migration and trigger apoptosis, G1 arrest in triple-negative breast cancer cells
por: Zhou, Yan, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_fpuq43pg861pkvf2u549ajenua