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Age as an independent factor for the development of neuropathy in diabetic patients

Population aging is unprecedented, without parallel in the history of humanity. As type 2 diabetes mellitus is predominantly more prevalent in aging populations, this creates a major public health burden. Older adults with diabetes have the highest rates of major lower-extremity amputation, myocardi...

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Autores principales: Popescu, Simona, Timar, Bogdan, Baderca, Flavia, Simu, Mihaela, Diaconu, Laura, Velea, Iulian, Timar, Romulus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801151/
https://www.ncbi.nlm.nih.gov/pubmed/27042031
http://dx.doi.org/10.2147/CIA.S97295
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author Popescu, Simona
Timar, Bogdan
Baderca, Flavia
Simu, Mihaela
Diaconu, Laura
Velea, Iulian
Timar, Romulus
author_facet Popescu, Simona
Timar, Bogdan
Baderca, Flavia
Simu, Mihaela
Diaconu, Laura
Velea, Iulian
Timar, Romulus
author_sort Popescu, Simona
collection PubMed
description Population aging is unprecedented, without parallel in the history of humanity. As type 2 diabetes mellitus is predominantly more prevalent in aging populations, this creates a major public health burden. Older adults with diabetes have the highest rates of major lower-extremity amputation, myocardial infarction, visual impairment, and end-stage renal disease of any age group. The aims of our study were to assess whether age is an independent factor for the occurrence of diabetic neuropathy (DN), and to evaluate the relationship between the presence and the severity of DN and the diabetes duration and blood glucose level. In this study, we enrolled 198 patients, previously diagnosed with type 2 diabetes mellitus. For all patients, we measured hemoglobin A(1c) (HbA(1c)), lipid profile, and body mass index and we assessed the presence and severity of DN using the evaluation of clinical signs and symptoms. Patients had a median age of 62 years, with a median of diabetes duration of 7 years; 55.1% of the patients were men and the average HbA(1c) in the cohort was 8.2%. The prevalence of DN according to Michigan Neuropathy Screening Instrument was 28.8%, being significantly and positively correlated with higher age (65 vs 59 years; P=0.001) and HbA(1c) (8.6% vs 8.0%; P=0.027). No significant correlations were observed between the severity of DN and diabetes duration, body mass index (31.9 vs 29.9 kg/m(2)), or the number of centimeters exceeding the normal waist circumference (25.2 vs 17.3 cm; P=0.003). In conclusion, age influences the presence of DN, independent on other risk factors. This influence persists even after adjusting for other, very important risk factors, like blood glucose level or diabetes duration.
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spelling pubmed-48011512016-04-01 Age as an independent factor for the development of neuropathy in diabetic patients Popescu, Simona Timar, Bogdan Baderca, Flavia Simu, Mihaela Diaconu, Laura Velea, Iulian Timar, Romulus Clin Interv Aging Original Research Population aging is unprecedented, without parallel in the history of humanity. As type 2 diabetes mellitus is predominantly more prevalent in aging populations, this creates a major public health burden. Older adults with diabetes have the highest rates of major lower-extremity amputation, myocardial infarction, visual impairment, and end-stage renal disease of any age group. The aims of our study were to assess whether age is an independent factor for the occurrence of diabetic neuropathy (DN), and to evaluate the relationship between the presence and the severity of DN and the diabetes duration and blood glucose level. In this study, we enrolled 198 patients, previously diagnosed with type 2 diabetes mellitus. For all patients, we measured hemoglobin A(1c) (HbA(1c)), lipid profile, and body mass index and we assessed the presence and severity of DN using the evaluation of clinical signs and symptoms. Patients had a median age of 62 years, with a median of diabetes duration of 7 years; 55.1% of the patients were men and the average HbA(1c) in the cohort was 8.2%. The prevalence of DN according to Michigan Neuropathy Screening Instrument was 28.8%, being significantly and positively correlated with higher age (65 vs 59 years; P=0.001) and HbA(1c) (8.6% vs 8.0%; P=0.027). No significant correlations were observed between the severity of DN and diabetes duration, body mass index (31.9 vs 29.9 kg/m(2)), or the number of centimeters exceeding the normal waist circumference (25.2 vs 17.3 cm; P=0.003). In conclusion, age influences the presence of DN, independent on other risk factors. This influence persists even after adjusting for other, very important risk factors, like blood glucose level or diabetes duration. Dove Medical Press 2016-03-15 /pmc/articles/PMC4801151/ /pubmed/27042031 http://dx.doi.org/10.2147/CIA.S97295 Text en © 2016 Popescu et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Popescu, Simona
Timar, Bogdan
Baderca, Flavia
Simu, Mihaela
Diaconu, Laura
Velea, Iulian
Timar, Romulus
Age as an independent factor for the development of neuropathy in diabetic patients
title Age as an independent factor for the development of neuropathy in diabetic patients
title_full Age as an independent factor for the development of neuropathy in diabetic patients
title_fullStr Age as an independent factor for the development of neuropathy in diabetic patients
title_full_unstemmed Age as an independent factor for the development of neuropathy in diabetic patients
title_short Age as an independent factor for the development of neuropathy in diabetic patients
title_sort age as an independent factor for the development of neuropathy in diabetic patients
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801151/
https://www.ncbi.nlm.nih.gov/pubmed/27042031
http://dx.doi.org/10.2147/CIA.S97295
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