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Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy

A mixture of docetaxel (DTX) and Solutol(®) HS 15 (Solutol) transiently formed nanodroplets when it was suspended in an aqueous medium. However, nanodroplets that comprised DTX and Solutol showed a rapid precipitation of DTX because of their unstable characteristics in the aqueous medium. The incorp...

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Autores principales: Oh, Keun Sang, Kim, Kyungim, Yoon, Byeong Deok, Lee, Hye Jin, Park, Dal Yong, Kim, Eun-yeong, Lee, Kiho, Seo, Jae Hong, Yuk, Soon Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801198/
https://www.ncbi.nlm.nih.gov/pubmed/27042062
http://dx.doi.org/10.2147/IJN.S100170
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author Oh, Keun Sang
Kim, Kyungim
Yoon, Byeong Deok
Lee, Hye Jin
Park, Dal Yong
Kim, Eun-yeong
Lee, Kiho
Seo, Jae Hong
Yuk, Soon Hong
author_facet Oh, Keun Sang
Kim, Kyungim
Yoon, Byeong Deok
Lee, Hye Jin
Park, Dal Yong
Kim, Eun-yeong
Lee, Kiho
Seo, Jae Hong
Yuk, Soon Hong
author_sort Oh, Keun Sang
collection PubMed
description A mixture of docetaxel (DTX) and Solutol(®) HS 15 (Solutol) transiently formed nanodroplets when it was suspended in an aqueous medium. However, nanodroplets that comprised DTX and Solutol showed a rapid precipitation of DTX because of their unstable characteristics in the aqueous medium. The incorporation of nanodroplets that comprised DTX and Solutol through vesicle fusion and subsequent stabilization was designed to prepare multilayer nanoparticles (NPs) with a DTX-loaded Solutol nanodroplet (as template NPs) core for an efficient delivery of DTX as a chemotherapeutic drug. As a result, the DTX-loaded Solutol nanodroplets (~11.7 nm) were observed to have an increased average diameter (from 11.7 nm to 156.1 nm) and a good stability of the hydrated NPs without precipitation of DTX by vesicle fusion and multilayered structure, respectively. Also, a long circulation of the multilayer NPs was observed, and this was due to the presence of Pluronic F-68 on the surface of the multilayer NPs. This led to an improved antitumor efficacy based on the enhanced permeation and retention effect. Therefore, this study indicated that the multilayer NPs have a considerable potential as a drug delivery system with an enhanced therapeutic efficacy by blood circulation and with low side effects.
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spelling pubmed-48011982016-04-01 Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy Oh, Keun Sang Kim, Kyungim Yoon, Byeong Deok Lee, Hye Jin Park, Dal Yong Kim, Eun-yeong Lee, Kiho Seo, Jae Hong Yuk, Soon Hong Int J Nanomedicine Original Research A mixture of docetaxel (DTX) and Solutol(®) HS 15 (Solutol) transiently formed nanodroplets when it was suspended in an aqueous medium. However, nanodroplets that comprised DTX and Solutol showed a rapid precipitation of DTX because of their unstable characteristics in the aqueous medium. The incorporation of nanodroplets that comprised DTX and Solutol through vesicle fusion and subsequent stabilization was designed to prepare multilayer nanoparticles (NPs) with a DTX-loaded Solutol nanodroplet (as template NPs) core for an efficient delivery of DTX as a chemotherapeutic drug. As a result, the DTX-loaded Solutol nanodroplets (~11.7 nm) were observed to have an increased average diameter (from 11.7 nm to 156.1 nm) and a good stability of the hydrated NPs without precipitation of DTX by vesicle fusion and multilayered structure, respectively. Also, a long circulation of the multilayer NPs was observed, and this was due to the presence of Pluronic F-68 on the surface of the multilayer NPs. This led to an improved antitumor efficacy based on the enhanced permeation and retention effect. Therefore, this study indicated that the multilayer NPs have a considerable potential as a drug delivery system with an enhanced therapeutic efficacy by blood circulation and with low side effects. Dove Medical Press 2016-03-16 /pmc/articles/PMC4801198/ /pubmed/27042062 http://dx.doi.org/10.2147/IJN.S100170 Text en © 2016 Oh et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Oh, Keun Sang
Kim, Kyungim
Yoon, Byeong Deok
Lee, Hye Jin
Park, Dal Yong
Kim, Eun-yeong
Lee, Kiho
Seo, Jae Hong
Yuk, Soon Hong
Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy
title Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy
title_full Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy
title_fullStr Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy
title_full_unstemmed Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy
title_short Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy
title_sort docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801198/
https://www.ncbi.nlm.nih.gov/pubmed/27042062
http://dx.doi.org/10.2147/IJN.S100170
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