Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches

Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modeling, mass spectrometry-based quantitation of network components, and experimental validation in MDA-MB-231 mesenchymal breast can...

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Detalles Bibliográficos
Autores principales: Byrne, Kate M., Monsefi, Naser, Dawson, John C., Degasperi, Andrea, Bukowski-Wills, Jimi-Carlo, Volinsky, Natalia, Dobrzyński, Maciej, Birtwistle, Marc R., Tsyganov, Mikhail A., Kiyatkin, Anatoly, Kida, Katarzyna, Finch, Andrew J., Carragher, Neil O., Kolch, Walter, Nguyen, Lan K., von Kriegsheim, Alex, Kholodenko, Boris N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802415/
https://www.ncbi.nlm.nih.gov/pubmed/27136688
http://dx.doi.org/10.1016/j.cels.2016.01.003

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