Supporting data for the effect of gamma-secretase inhibitors in osteoclast differentiation and spreading

The data in this article is related to the research article entitled “Notch2 signaling promotes osteoclast resorption via activation of PYK2” (Jin et al., 2016 [1]). To block Notch signaling activation, we used several gamma-secretase inhibitors (GSIs) and evaluate the inhibitory potential of GSIs o...

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Detalles Bibliográficos
Autores principales: Jin, Won Jong, Kim, Bongjun, Kim, Jung-Wook, Kim, Hong-Hee, Ha, Hyunil, Lee, Zang Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802519/
https://www.ncbi.nlm.nih.gov/pubmed/27054177
http://dx.doi.org/10.1016/j.dib.2016.03.018
Descripción
Sumario:The data in this article is related to the research article entitled “Notch2 signaling promotes osteoclast resorption via activation of PYK2” (Jin et al., 2016 [1]). To block Notch signaling activation, we used several gamma-secretase inhibitors (GSIs) and evaluate the inhibitory potential of GSIs on osteoclastogenesis. We measured the effect of GSIs on osteoclastogenesis and normal spreading of osteoclasts by using the mouse bone marrow-derived macrophages (BMMs) which may contributes to insight of physiological relevant of in vivo. This data article suggests valuable approach to GSIs treatment doses and potential of those in the osteoclast differentiation and spreading.

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