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Kinetics of cytochrome P450 enzymes for metabolism of sodium tanshinone IIA sulfonate in vitro

BACKGROUND: Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA for treating cardiovascular disorders. The roles of cytochrome P450 enzymes (CYPs) in the metabolism of STS have remained unclear. This study aims to screen the main CYPs for metabolism of STS and study...

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Detalles Bibliográficos
Autores principales:	Ouyang, Dong-sheng, Huang, Wei-hua, Chen, Dan, Zhang, Wei, Tan, Zhi-rong, Peng, Jing-bo, Wang, Yi-cheng, Guo, Ying, Hu, Dong-li, Xiao, Jian, Chen, Yao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802617/ https://www.ncbi.nlm.nih.gov/pubmed/27006687 http://dx.doi.org/10.1186/s13020-016-0083-z

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