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Angiostrongylus vasorum in the eye: new case reports and a review of the literature

BACKGROUND: Nematodes of the genus Angiostrongylus are important causes of potentially life-threatening diseases in several animal species and humans. Angiostrongylus vasorum affects the right ventricle of the heart and the pulmonary arteries in dogs, red foxes and other carnivores. The diagnosis of...

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Autores principales: Colella, Vito, Lia, Riccardo Paolo, Premont, Johana, Gilmore, Paul, Cervone, Mario, Latrofa, Maria Stefania, D’Anna, Nunzio, Williams, Diana, Otranto, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802644/
https://www.ncbi.nlm.nih.gov/pubmed/27000634
http://dx.doi.org/10.1186/s13071-016-1440-6
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author Colella, Vito
Lia, Riccardo Paolo
Premont, Johana
Gilmore, Paul
Cervone, Mario
Latrofa, Maria Stefania
D’Anna, Nunzio
Williams, Diana
Otranto, Domenico
author_facet Colella, Vito
Lia, Riccardo Paolo
Premont, Johana
Gilmore, Paul
Cervone, Mario
Latrofa, Maria Stefania
D’Anna, Nunzio
Williams, Diana
Otranto, Domenico
author_sort Colella, Vito
collection PubMed
description BACKGROUND: Nematodes of the genus Angiostrongylus are important causes of potentially life-threatening diseases in several animal species and humans. Angiostrongylus vasorum affects the right ventricle of the heart and the pulmonary arteries in dogs, red foxes and other carnivores. The diagnosis of canine angiostrongylosis may be challenging due to the wide spectrum of clinical signs. Ocular manifestations have been seldom reported but have serious implications for patients. METHODS: The clinical history of three cases of infection with A. vasorum in dogs diagnosed in UK, France and Italy, was obtained from clinical records provided by the veterinary surgeons along with information on the diagnostic procedures and treatment. Nematodes collected from the eyes of infected dogs were morphologically identified to the species level and molecularly analysed by the amplification of the nuclear 18S rRNA gene. RESULTS: On admission, the dogs were presented with various degrees of ocular discomfort and hyphema because of the presence of a motile object in the eye. The three patients had ocular surgery during which nematodes were removed and subsequently morphologically and molecularly identified as two adult males and one female of A. vasorum. CONCLUSIONS: Three new cases of canine ocular angiostrongylosis are reported along with a review of other published clinical cases to improve the diagnosis and provide clinical recommendation for this parasitic condition. In addition, the significance of migratory patterns of larvae inside the host body is discussed. Veterinary healthcare workers should include canine angiostrongylosis in the differential diagnosis of ocular diseases. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13071-016-1440-6) contains supplementary material, which is available to authorized users.
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spelling pubmed-48026442016-03-22 Angiostrongylus vasorum in the eye: new case reports and a review of the literature Colella, Vito Lia, Riccardo Paolo Premont, Johana Gilmore, Paul Cervone, Mario Latrofa, Maria Stefania D’Anna, Nunzio Williams, Diana Otranto, Domenico Parasit Vectors Research BACKGROUND: Nematodes of the genus Angiostrongylus are important causes of potentially life-threatening diseases in several animal species and humans. Angiostrongylus vasorum affects the right ventricle of the heart and the pulmonary arteries in dogs, red foxes and other carnivores. The diagnosis of canine angiostrongylosis may be challenging due to the wide spectrum of clinical signs. Ocular manifestations have been seldom reported but have serious implications for patients. METHODS: The clinical history of three cases of infection with A. vasorum in dogs diagnosed in UK, France and Italy, was obtained from clinical records provided by the veterinary surgeons along with information on the diagnostic procedures and treatment. Nematodes collected from the eyes of infected dogs were morphologically identified to the species level and molecularly analysed by the amplification of the nuclear 18S rRNA gene. RESULTS: On admission, the dogs were presented with various degrees of ocular discomfort and hyphema because of the presence of a motile object in the eye. The three patients had ocular surgery during which nematodes were removed and subsequently morphologically and molecularly identified as two adult males and one female of A. vasorum. CONCLUSIONS: Three new cases of canine ocular angiostrongylosis are reported along with a review of other published clinical cases to improve the diagnosis and provide clinical recommendation for this parasitic condition. In addition, the significance of migratory patterns of larvae inside the host body is discussed. Veterinary healthcare workers should include canine angiostrongylosis in the differential diagnosis of ocular diseases. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13071-016-1440-6) contains supplementary material, which is available to authorized users. BioMed Central 2016-03-21 /pmc/articles/PMC4802644/ /pubmed/27000634 http://dx.doi.org/10.1186/s13071-016-1440-6 Text en © Colella et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Colella, Vito
Lia, Riccardo Paolo
Premont, Johana
Gilmore, Paul
Cervone, Mario
Latrofa, Maria Stefania
D’Anna, Nunzio
Williams, Diana
Otranto, Domenico
Angiostrongylus vasorum in the eye: new case reports and a review of the literature
title Angiostrongylus vasorum in the eye: new case reports and a review of the literature
title_full Angiostrongylus vasorum in the eye: new case reports and a review of the literature
title_fullStr Angiostrongylus vasorum in the eye: new case reports and a review of the literature
title_full_unstemmed Angiostrongylus vasorum in the eye: new case reports and a review of the literature
title_short Angiostrongylus vasorum in the eye: new case reports and a review of the literature
title_sort angiostrongylus vasorum in the eye: new case reports and a review of the literature
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802644/
https://www.ncbi.nlm.nih.gov/pubmed/27000634
http://dx.doi.org/10.1186/s13071-016-1440-6
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